non-specific protein-tyrosine kinase

non-specific protein-tyrosine kinase
non-spe·cif·ic pro·tein-ty·ro·sine ki·nase (non″spə-sifґik proґtēn tiґro-sēn kiґnās) [EC] a group comprising those protein-tyrosine kinases that lack a transmembrane domain. They are further divided into families (e.g., JAK kinases), which differ structurally but which are involved in signaling pathways important in processes such as cell growth, differentiation, and adhesion, in lymphocyte activation, and in oncogenesis. Cf. receptor protein-tyrosine kinase.

Medical dictionary. 2011.

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  • Non-specific protein-tyrosine kinase — In enzymology, a non specific protein tyrosine kinase (EC number| is an enzyme that catalyzes the chemical reaction:ATP + a [protein] L tyrosine ightleftharpoons ADP + a [protein] L tyrosine phosphateThus, the two substrates of this… …   Wikipedia

  • protein-tyrosine kinase — pro·tein ty·ro·sine ki·nase (proґtēn tiґro sēn kiґnās) [EC 2.7.10] a group comprising the protein kinases that catalyze the phosphorylation of tyrosine residues in specific proteins. It is subdivided into the receptor protein… …   Medical dictionary

  • receptor protein-tyrosine kinase — re·cep·tor pro·tein ty·ro·sine ki·nase (re sepґtər proґtēn tiґro sēn kiґnās) [EC] a group comprising those protein tyrosine kinases with a transmembrane domain and cytoplasmic tyrosine kinase activity. They are… …   Medical dictionary

  • Non-receptor tyrosine kinase — non membrane spanning protein tyrosine kinase Identifiers EC number Databases IntEnz In …   Wikipedia

  • Protein tyrosine phosphatase — Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post translational modification that can create novel… …   Wikipedia

  • Bruton tyrosine kinase — (BTK) Bru·ton ty·ro·sine ki·nase (BTK) (brooґtən tiґro sēn kiґnās) a nonreceptor tyrosine kinase (non specific protein tyrosine kinase, q.v.) that plays an important role in signaling in B cell activation and differentiation;… …   Medical dictionary

  • Tyrosine kinase — A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. Phosphorylation of proteins by kinases is an important… …   Wikipedia

  • Src tyrosine kinase — Src ty·ro·sine ki·nase (sahrk tiґro sēn kiґnās) a family of related non specific protein tyrosine kinases, the prototype of which is the protein encoded by the SRC proto oncogene; they are highly conserved, act as cellular switches for… …   Medical dictionary

  • Megakaryocyte-associated tyrosine kinase — PDB rendering based on 1jwo …   Wikipedia

  • Bcr-Abl tyrosine-kinase inhibitor — Bcr Abl tyrosine kinase inhibitors (TKI) are the first line therapy for most patients with chronic myelogenous leukemia (CML). In more than 90% cases CML is caused by chromosomal abnormality resulting in the formation of a so called Philadelphia… …   Wikipedia

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