receptor protein-tyrosine kinase
- receptor protein-tyrosine kinase
- re·cep·tor pro·tein-ty·ro·sine ki·nase (re-sepґtər proґtēn tiґro-sēn kiґnās) [EC 2.7.10.1] a group comprising those protein-tyrosine kinases with a transmembrane domain and cytoplasmic tyrosine kinase activity. They are involved in cellular signaling pathways; binding of extracellular growth factor ligands (e.g., epidermal growth factor, fibroblast growth factors, transforming growth factor-α, platelet-derived growth factor, insulin) leads to dimerization and activation of receptors, autophosphorylation, and then binding and activation of effector proteins that control cellular proliferation and differentiation. Cf. non-specific protein-tyrosine kinase.
Medical dictionary.
2011.
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protein-tyrosine kinase — pro·tein ty·ro·sine ki·nase (proґtēn tiґro sēn kiґnās) [EC 2.7.10] a group comprising the protein kinases that catalyze the phosphorylation of tyrosine residues in specific proteins. It is subdivided into the receptor protein… … Medical dictionary
non-specific protein-tyrosine kinase — non spe·cif·ic pro·tein ty·ro·sine ki·nase (non″spə sifґik proґtēn tiґro sēn kiґnās) [EC 2.7.10.2] a group comprising those protein tyrosine kinases that lack a transmembrane domain. They are further divided into… … Medical dictionary
Non-specific protein-tyrosine kinase — In enzymology, a non specific protein tyrosine kinase (EC number|2.7.10.2) is an enzyme that catalyzes the chemical reaction:ATP + a [protein] L tyrosine ightleftharpoons ADP + a [protein] L tyrosine phosphateThus, the two substrates of this… … Wikipedia
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Megakaryocyte-associated tyrosine kinase — PDB rendering based on 1jwo … Wikipedia
