receptor protein-tyrosine kinase

receptor protein-tyrosine kinase
re·cep·tor pro·tein-ty·ro·sine ki·nase (re-sepґtər proґtēn tiґro-sēn kiґnās) [EC] a group comprising those protein-tyrosine kinases with a transmembrane domain and cytoplasmic tyrosine kinase activity. They are involved in cellular signaling pathways; binding of extracellular growth factor ligands (e.g., epidermal growth factor, fibroblast growth factors, transforming growth factor-α, platelet-derived growth factor, insulin) leads to dimerization and activation of receptors, autophosphorylation, and then binding and activation of effector proteins that control cellular proliferation and differentiation. Cf. non-specific protein-tyrosine kinase.

Medical dictionary. 2011.

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