protein-tyrosine kinase

protein-tyrosine kinase
pro·tein-ty·ro·sine ki·nase (proґtēn tiґro-sēn kiґnās) [EC 2.7.10] a group comprising the protein kinases that catalyze the phosphorylation of tyrosine residues in specific proteins. It is subdivided into the receptor protein-tyrosine kinases and the non-specific protein tyrosine kinases (qq.v.). The enzymes play a variety of roles in the control of cell growth and differentiation. Many of the known oncogenes and proto-oncogenes involved in cancer encode protein-tyrosine kinases, and unregulated activation of these enzymes can lead to oncogenesis as well as to various benign proliferative conditions.

Medical dictionary. 2011.

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  • Non-specific protein-tyrosine kinase — In enzymology, a non specific protein tyrosine kinase (EC number| is an enzyme that catalyzes the chemical reaction:ATP + a [protein] L tyrosine ightleftharpoons ADP + a [protein] L tyrosine phosphateThus, the two substrates of this… …   Wikipedia

  • receptor protein-tyrosine kinase — re·cep·tor pro·tein ty·ro·sine ki·nase (re sepґtər proґtēn tiґro sēn kiґnās) [EC] a group comprising those protein tyrosine kinases with a transmembrane domain and cytoplasmic tyrosine kinase activity. They are… …   Medical dictionary

  • non-specific protein-tyrosine kinase — non spe·cif·ic pro·tein ty·ro·sine ki·nase (non″spə sifґik proґtēn tiґro sēn kiґnās) [EC] a group comprising those protein tyrosine kinases that lack a transmembrane domain. They are further divided into… …   Medical dictionary

  • nonreceptor protein-tyrosine kinase — See tyrosine kinase …   Dictionary of molecular biology

  • Protein tyrosine phosphatase — Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine (pTyr) phosphorylation is a common post translational modification that can create novel… …   Wikipedia

  • Tyrosine kinase 2 — Tyrosine kinase 2, also known as TYK2, is a human gene.cite web | title = Entrez Gene: TYK2 tyrosine kinase 2| url = Cmd=ShowDetailView TermToSearch=7297| accessdate = ] Tyk2 was the first member… …   Wikipedia

  • Tyrosine kinase — A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. Phosphorylation of proteins by kinases is an important… …   Wikipedia

  • tyrosine kinase inhibitor — any of a class of antineoplastic agents that inhibit protein tyrosine kinase and interfere with the action of epidermal growth factor in cancer cells …   Medical dictionary

  • tyrosine kinase — ty·ro·sine ki·nase (tiґro sēn kiґnās) protein tyrosine kinase …   Medical dictionary

  • Receptor tyrosine kinase — Receptor tyrosine kinases (RTK)s are the high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. Of the ninety unique tyrosine kinase genes idenitified in the human genome, 58 encode receptor tyrosine… …   Wikipedia

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