Src tyrosine kinase

Src tyrosine kinase: Src ty·ro·sine ki·nase (sahrk tiґro-sēn kiґnās) a family of related non-specific protein-tyrosine kinases, the prototype of which is the protein encoded by the SRC proto-oncogene; they are highly conserved, act as cellular switches for growth and differentiation, and are themselves controlled by phosphorylation. They are normally kept in the inactive state by regulatory segments that cover the active site of the protein; mutations that alter protein activity have been associated with various forms of cancer, including small-cell lung, colon, and breast carcinomas, neuroblastoma, and rhabdomyosarcoma.

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C-src tyrosine kinase — C src tyrosine kinase, also known as CSK, is a human protein and gene. It includes an SH2 domain, an SH3 domain, and a tyrosine kinase domain. This protein specifically phosphorylates Tyr 504 residue on human leukocyte specific protein tyrosine… … Wikipedia
Tyrosine kinase — A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. Phosphorylation of proteins by kinases is an important… … Wikipedia
Receptor tyrosine kinase — Receptor tyrosine kinases (RTK)s are the high affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones. Of the ninety unique tyrosine kinase genes idenitified in the human genome, 58 encode receptor tyrosine… … Wikipedia
Bcr-Abl tyrosine-kinase inhibitor — Bcr Abl tyrosine kinase inhibitors (TKI) are the first line therapy for most patients with chronic myelogenous leukemia (CML). In more than 90% cases CML is caused by chromosomal abnormality resulting in the formation of a so called Philadelphia… … Wikipedia
Src (gene) — Src is a family of proto oncogenic tyrosine kinases originally discovered by J. Michael Bishop and Harold E. Varmus, for which they won the Nobel Prize. [ [http://nobelprize.org/nobel prizes/medicine/laureates/1989/press.html Nobel Prize in… … Wikipedia
Megakaryocyte-associated tyrosine kinase — PDB rendering based on 1jwo … Wikipedia
Non-receptor tyrosine kinase — non membrane spanning protein tyrosine kinase Identifiers EC number 2.7.10.2 Databases IntEnz In … Wikipedia
Non-specific protein-tyrosine kinase — In enzymology, a non specific protein tyrosine kinase (EC number|2.7.10.2) is an enzyme that catalyzes the chemical reaction:ATP + a [protein] L tyrosine ightleftharpoons ADP + a [protein] L tyrosine phosphateThus, the two substrates of this… … Wikipedia
AXL receptor tyrosine kinase — AXL receptor tyrosine kinase, also known as AXL, is a human gene.cite web | title = Entrez Gene: AXL AXL receptor tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=558| accessdate = ] PBB… … Wikipedia
SRC — sedimented red cells; sheep red cells; signed reaction center; steroid receptor * * * (sahrk) a human proto oncogene homologous to the v src oncogene first identified as the transforming determinant in Rous sarcoma virus; it encodes Src tyrosine… … Medical dictionary

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Src tyrosine kinase

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