allosteric site

allosteric site
a specific site on a multi-subunit enzyme that is not the substrate binding site but that when reversibly bound by an effector induces a conformational change in the enzyme, altering its catalytic properties.

Medical dictionary. 2011.

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  • allosteric site — That part of an enzyme molecule where the non covalent binding of an effector molecule can affect the enzyme s catalytic activity. See: conformation, ligand …   Glossary of Biotechnology

  • Allosteric regulation — In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein s allosteric site (that is, a site other than the protein s active site). Effectors that enhance the protein s… …   Wikipedia

  • allosteric control — Inhibition or activation of an enzyme by a small regulatory molecule that interacts with the enzyme at a site (allosteric site) other than the active site (at which catalytic activity occurs). The interaction changes the shape of the enzyme, thus …   Universalium

  • allosteric — Of a binding site in a protein, usually an enzyme. The catalytic function of an enzyme may be modified by interaction with small molecules, not only at the active site, but also at a spatially distinct (allosteric) site of different specificity.… …   Dictionary of molecular biology

  • allosteric activation — increase in enzyme activity by binding of an effector at an allosteric site that causes at the catalytic site either increased binding affinity of the enzyme for the substrate or increased rate of catalytic turnover …   Medical dictionary

  • allosteric inhibition — inhibition of an enzyme by binding of an inhibitor at an allosteric site that causes at the catalytic site either reduced binding affinity of the enzyme for the substrate or decreased rate of catalytic turnover …   Medical dictionary

  • Allosteric enzyme — Allosteric enzymes are enzymes that change their shape, or conformation, upon binding of a modulator. The word allosteric comes from the Greek allos, other and stereos , shape . An allosteric enzyme is an oligomer whose biological activity is… …   Wikipedia

  • site — A place or location or locus. SYN: situs. [L. situs] acceptor s. the ribosomal binding s. for the aminoacyl tRNA during protein synthesis. acceptor splicing s. SYN: right splicing junction. active s. that portion of an …   Medical dictionary

  • allosteric enzyme — (al o ster ik) An enzyme whose activity is altered by the binding of a small effector or modulator molecule at a regulatory site separate from the catalytic site; effector binding causes a conformational change in the enzyme and its catalytic… …   Dictionary of microbiology

  • allosteric effector — an enzyme inhibitor or activator that has its effect at a site other than the catalytic site of the enzyme; see also under site, and see allostery …   Medical dictionary

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