Medical dictionary. 2011.
Allosteric regulation — In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein s allosteric site (that is, a site other than the protein s active site). Effectors that enhance the protein s… … Wikipedia
allosteric control — Inhibition or activation of an enzyme by a small regulatory molecule that interacts with the enzyme at a site (allosteric site) other than the active site (at which catalytic activity occurs). The interaction changes the shape of the enzyme, thus … Universalium
Allosteric serotonin reuptake inhibitor — is a marketing classification invented by the pharmaceutical company Lundbeck for its selective serotonin reuptake inhibitor (SSRI) escitalopram, the S stereoisomer of the SSRI citalopram. It is based on the observation that the R isomer of… … Wikipedia
inhibition — /in i bish euhn, in hi /, n. 1. the act of inhibiting. 2. the state of being inhibited. 3. something that inhibits; constraint. 4. Psychol. a. the blocking or holding back of one psychological process by another. b. inappropriate conscious or… … Universalium
allosteric enzyme — (al o ster ik) An enzyme whose activity is altered by the binding of a small effector or modulator molecule at a regulatory site separate from the catalytic site; effector binding causes a conformational change in the enzyme and its catalytic… … Dictionary of microbiology
Competitive inhibition — is a form of enzyme inhibition where binding of the inhibitor to the active site on the enzyme prevents binding of the substrate and vice versa. Contents 1 Mechanism 2 Equation 3 Derivation 4 … Wikipedia
Non-competitive inhibition — is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme, by binding not to the active site on the enzyme, but to a different site.[1] More specifically, it is a special instance of mixed inhibition where the… … Wikipedia
feedback inhibition — Suppression of the activity of an enzyme by a product of the sequence of reactions in which the enzyme is participating. When the product accumulates in a cell beyond an optimal amount, it decreases its own production by inhibiting an enzyme… … Universalium
Negative allosteric modulator — A negative allosteric modulator (NAM) is a drug which decreases the activity of a receptor indirectly via disactivation of an allosteric site on the protein. NAMs are similar to inverse agonists in that they conteract overall receptor activation … Wikipedia
enzyme — /en zuym/, n. Biochem. any of various proteins, as pepsin, originating from living cells and capable of producing certain chemical changes in organic substances by catalytic action, as in digestion. Cf. ase. [1880 85; < MGk énzymos leavened (Gk… … Universalium
