isocitrate dehydrogenase (NAD+)
- isocitrate dehydrogenase (NAD+)
- iso·ci·trate de·hy·dro·gen·ase (NAD+) (i″so-sĭґtrāt de-hiґdrə-jən-ās) [EC 1.1.1.41] a mitochondrial enzyme that catalyzes the oxidative decarboxylation of isocitrate to form α-ketoglutarate, using NAD+ as an electron acceptor; the reaction is the key rate-limiting step of the tricarboxylic acid cycle. The enzyme requires Mg2+ or Mn2+ and is activated by ADP, citrate, and Ca2+ and inhibited by NADH, NADPH, and ATP.
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Isocitrate dehydrogenase — (EC number|1.1.1.42) and (EC number|1.1.1.41), also known as IDH, is an enzyme which participates in the citric acid cycle. It catalyzes the third step of the cycle: the oxidative decarboxylation of isocitrate, producing alpha ketoglutarate (α… … Wikipedia
isocitrate dehydrogenase — isocitrate de·hy·dro·ge·nase .dē (.)hī dräj e .nās, ( )dē hī drə jə , .nāz n either of two enzymes which catalyze the oxidation of isocitric acid to alpha ketoglutaric acid (as in the Krebs cycle) and of which one uses NAD as an electron acceptor … Medical dictionary
Dehydrogenase — A dehydrogenase (also called DHO in the literature) is an enzyme that oxidises a substrate by a reduction reaction that transfers one or more hydrides (H−) to an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN.… … Wikipedia
dehydrogenase — Class name for those enzymes that oxidize substrates by catalyzing removal of hydrogen from metabolites (hydrogen donors) and transferring it to other substances (hydrogen acceptors), which are thus reduced; most of the oxidative enzymes… … Medical dictionary
isocitrate — A salt or ester of isocitric acid. i. dehydrogenase one of two enzymes that catalyze the conversion of threo ds i., the product of the action of both aconitase and i. lyase, to α ketoglutarate (2 oxoglutarate) and CO2; one of the isozymes uses … Medical dictionary
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