- dehydrogenase
- Class name for those enzymes that oxidize substrates by catalyzing removal of hydrogen from metabolites (hydrogen donors) and transferring it to other substances (hydrogen acceptors), which are thus reduced; most of the oxidative enzymes (oxidoreductases, EC class 1) perform their oxidations in this manner.- aerobic d. an enzyme (usually a metalloflavoenzyme) catalyzing the transfer of hydrogen from some metabolite to oxygen, forming hydrogen peroxide in the process; e.g., xanthine oxidase and others in several sub-subclasses ( e.g., EC 1.1.3, 1.2.3, 1.7.3, 1.8.3, 1.10.3).- anaerobic d. an enzyme (usually a pyridinoenzyme) catalyzing the transfer of hydrogen from some metabolite to some acceptor molecule ( e.g., NAD+, cytochrome) other than oxygen; e.g., lactate dehydrogenases, isocitrate dehydrogenases, and others in EC class 1, excluding those listed under aerobic d..- α-keto acid d. See α-keto acid d..
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de·hy·dro·ge·nase .dē-(.)hī-'dräj-ə-.nās, (')dē-'hī-drə-jə-, -.nāz n an enzyme that accelerates the removal of hydrogen from metabolites and its transfer to other substances see SUCCINATE DEHYDROGENASE* * *
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de·hy·dro·gen·ase (de-hiґdro-jən″ās) an enzyme of the oxidoreductase class [EC 1] that catalyzes the transfer of hydrogen or electrons from a donor, which becomes oxidized, to an acceptor compound, which becomes reduced. Dehydrogenases are usually designated according to the hydrogen donor.
Medical dictionary. 2011.
