von Willebrand factor

von Willebrand factor
von Wil·le·brand factor vän-'vil-ə-.bränt- n a protein secreted esp. by endothelial cells that circulates in blood plasma as a large variable aggregation consisting usu. of repeating dimers, that mediates platelet adhesion to collagen in subendothelial tissue at injury sites, that is often found complexed to factor VIII in plasma where it serves to protect it from degradation, and that is deficient or defective in individuals affected with von Willebrand's disease called also VW factor
Willebrand Erik Adolf von (1870-1949)
Finnish physician. He described von Willebrand's disease first in 1926 and again in 1931 in a follow-up article.

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(vWF) a glycoprotein synthesized in endothelial cells and megakaryocytes that circulates complexed to factor VIII (see under coagulation f's); it mediates adhesion of platelets to damaged epithelial surfaces and may participate in platelet aggregation. Deficiency results in the prolonged bleeding time seen in von Willebrand disease. NOTE: this factor was originally considered to be part of factor VIII, so that in older terminology the term factor VIII generally refers to the complex of the two factors.

Medical dictionary. 2011.

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  • Von Willebrand factor — (vWF) is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde s syndrome, and possibly… …   Wikipedia

  • von Willebrand factor — von Willebrand factor. См. фактор фон Виллебранда. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • von Willebrand factor — Plasma factor involved in platelet adhesion through an interaction with Factor VIII. See von Willebrand s disease …   Dictionary of molecular biology

  • von Willebrand's disease — von Wil·le·brand s disease .bränts n a genetic disorder that is caused by deficient or defective von Willebrand factor, is characterized by mucosal and petechial bleeding due to abnormal blood vessels, and is inherited chiefly as an autosomal… …   Medical dictionary

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  • von Willebrand disease — ▪ pathology       inherited blood disorder (blood disease) characterized by a prolonged bleeding time and a deficiency of factor VIII, an important blood clotting agent. This disorder is due to deficiencies in von Willebrand factor (vWF), a… …   Universalium

  • von Willebrand's disease — an inherited disorder of the blood that is characterized by episodes of spontaneous bleeding similar to haemophilia. It is due to a variety of abnormalities of the von Willebrand factor, a glycoprotein necessary for normal platelet function. This …   Medical dictionary

  • von Willebrand's disease — an inherited disorder of the blood that is characterized by episodes of spontaneous bleeding similar to haemophilia. It is due to a variety of abnormalities of the von Willebrand factor, a glycoprotein necessary for normal platelet function. This …   The new mediacal dictionary

  • von Willebrand disease — a congenital bleeding disorder, usually of autosomal dominant inheritance, characterized by deficiency of von Willebrand factor, with prolonged bleeding time and often impairment of adhesion of platelets on glass beads, associated with epistaxis… …   Medical dictionary

  • Factor de von Willebrand — Saltar a navegación, búsqueda Factor von Willebrand Identificadores Símbolo VWF Símbolos alt. F8VWF Entrez …   Wikipedia Español

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