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any of a group of substances that have the ability to cleave plasminogen and convert it into plasmin, its active form; see t-plasminogen a. and u-plasminogen a.Medical dictionary. 2011.
Plasminogen activator — A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis.Types include: * The gene tissue plasminogen activator (PLAT) * The gene Plasminogen activator, urokinase (PLAU)It is inhibited by… … Wikipedia
plasminogen activator — Serine protease that acts on plasminogen to generate plasmin. Has also been implicated in invasiveness, and is produced by many normal and invasive cells. The vascular form (tPA; 55 kD) is very similar to tissue plasminogen activator (uPA; 70 kD) … Dictionary of molecular biology
Plasminogen activator inhibitor-1 — Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 PAI 1 in complex with the SMB domain of Vitronectin PDB 1OC0 … Wikipedia
Plasminogen activator inhibitor-2 — Serpin peptidase inhibitor, clade B (ovalbumin), member 2 PDB rendering based on 1by7 … Wikipedia
plasminogen activator inhibitor — (PAI) any of several members of the serpin group, regulators of fibrinolysis that act by binding to and inhibiting free plasminogen activator. The concentration in plasma of the inhibitors is normally low, but is altered in some disturbances of… … Medical dictionary
plasminogen activator — noun protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis • Syn: ↑urokinase • Hypernyms: ↑protease, ↑peptidase, ↑proteinase, ↑proteolytic enzyme … Useful english dictionary
Tissue plasminogen activator — (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots. Specifically, it is a serine protease (EC number|3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the… … Wikipedia
u-plasminogen activator — [EC 3.4.21.73] urinary plasminogen activator a serine endopeptidase that acts as a plasminogen activator by catalyzing the preferential cleavage of plasminogen at the same arginine valine bond where t plasminogen activator (t PA) cleaves. It is… … Medical dictionary
tissue plasminogen activator — n a clot dissolving enzyme that has an affinity for fibrin, that catalyzes the conversion of plasminogen to plasmin, that is produced naturally in blood vessel linings, and that is used in a genetically engineered form to prevent damage to heart… … Medical dictionary
tissue plasminogen activator — noun a thrombolytic agent (trade name Activase) that causes fibrinolysis at the site of a blood clot; used in treating acute myocardial infarction • Syn: ↑Activase • Usage Domain: ↑trade name (for: ↑Activase) • Hypernyms: ↑ … Useful english dictionary
