plasminogen activator inhibitor
- plasminogen activator inhibitor
- (PAI) any of several members of the serpin group, regulators of fibrinolysis that act by binding to and inhibiting free plasminogen activator. The concentration in plasma of the inhibitors is normally low, but is altered in some disturbances of the hemostatic system. PAI-1 is an important fast-reacting inhibitor of t-PA and u-PA; its synthesis, activity, and release are highly regulated, and elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is another name for protein C inhibitor.
Medical dictionary.
2011.
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PAI-1 — plasminogen activator inhibitor 1 … Medical dictionary
