primed lymphocyte typing

primed lymphocyte typing
(PLT) a technique used for typing of Class II HLA antigens: unknown cells are exposed to a panel of lymphocytes primed against specific HLA antigens by prior coculture with stimulator cells that matched the primed cells at all but one HLA locus; when restimulated by the same HLA antigen the primed cells give a secondary proliferative response, which shows that the unknown cells bear the same antigen as the stimulator cells.

Medical dictionary. 2011.

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  • HLA typing — determination of the human leukocyte antigens (HLA) possessed by an individual. Class I antigens (HLA A, B, and C) are detected by lymphocyte microcytotoxicity assay using standard typing sera. Class II antigens are detected by one way mixed… …   Medical dictionary

  • PLT — platelet; primary lymphoma of the thyroid; primed lymphocyte test; primed lymphocyte typing; psittacosis lymphogranuloma venereum trachoma [group] * * * primed lymphocyte typing …   Medical dictionary

  • PLT — • platelet; • primary lymphoma of the thyroid; • primed lymphocyte test; • primed lymphocyte typing; • psittacosislymphogranuloma venereum trachoma [group] …   Dictionary of medical acronyms & abbreviations

  • human leukocyte antigens — (HLA) histocompatibility antigens governed by genes of the HLA complex (the human major histocompatibility complex), a region on the short arm of chromosome 6 containing several genetic loci, each having multiple alleles. Loci are designated by… …   Medical dictionary

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