human leukocyte antigens

human leukocyte antigens
(HLA) histocompatibility antigens governed by genes of the HLA complex (the human major histocompatibility complex), a region on the short arm of chromosome 6 containing several genetic loci, each having multiple alleles. Loci are designated by letters; the classical loci are HLA-A, -B, -C, -E, -F, -G, -DP, -DQ, and -DR (there are at least three subloci in the D region). Alleles at each locus are designated by numbers, e.g., HLA-A1, provisional designations being indicated by “w” (for “workshop”), e.g., HLA-DRw10. The A, B, C, and DR antigens are defined and typed by serologic reactions. The D antigens are defined and typed by one-way mixed lymphocyte culture (MLC) using panels of HLA-D-homozygous typing cells. The SB (for “secondary B cell”) antigens are defined and typed by primed lymphocyte typing. See class I, class II, and class III a's.

Medical dictionary. 2011.

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