HLA typing

HLA typing
determination of the human leukocyte antigens (HLA) possessed by an individual. Class I antigens (HLA-A, -B, and -C) are detected by lymphocyte microcytotoxicity assay using standard typing sera. Class II antigens are detected by one-way mixed lymphocyte cultures using panels of homozygous typing cells; they may also be identified by primed lymphocyte typing (q.v.). DR Class II antigens are also detected by lymphocyte microtoxicity assay using B lymphocytes and anti-DR antibody types. HLA typing is used to identify compatible donors and recipients for transplantation or platelet or granulocyte transfusion, to establish associations of human leukocyte antigens with diseases, and in paternity testing.

Medical dictionary. 2011.

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  • HLA-DR6 — (DR6) is a broad antigen serotype that is further split into HLA DR13 and HLA DR14 antigen serotypes.erologyDR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.Disease… …   Wikipedia

  • HLA-DQ9 — heteroisoform isoformgroup = HLA DQ9 polymer type = MHC Class II, DQ cell surface antigen image source = Illustration of HLA DQ with bound peptide. isoformCount = 2 subunit1 = DQA1 subunit2 = DQB1 isoform1 = DQ α2β9 nick1 = DQ9.2 allele1a =… …   Wikipedia

  • HLA-DQ5 — heteroisoform isoformgroup = HLA DQ5 polymer type = MHC Class II, DQ cell surface antigen image source = Illustration of HLA DQ with gliadin peptide in the binding pocket. isoformCount = 3 subunit1 = DQA1 subunit2 = DQB1 isoform1 = DQ α1.1β5.1… …   Wikipedia

  • HLA — The major human histocompatibility system. HLA typing is done before transplantation to determine the degree of histocompatibility. HLA is an acronym for Human Leukocyte Antigens. * * * Abbreviation for human leukocyte antigens, under antigen. *… …   Medical dictionary

  • HLA-DQ8 — (MHC Class II, DQ cell surface antigen) Rendering of HLA DQ8 with immundoinant insulin peptide in the binding pocket. Cis haplotype Haplotype …   Wikipedia

  • HLA-B27 — HLA B27, α Kette Vorhandene Strukturdaten: s. UniProt Masse/Länge …   Deutsch Wikipedia

  • HLA-DR3 — is composed to the HLA DR17 and HLA DR18 split antigens serotypes. DR3 is a component gene allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune… …   Wikipedia

  • HLA-DQ3 — (DQ3) is a broad serotype category with split antigens HLA DQ7, DQ8, and DQ9. Historically, originally recognized as MB3cite journal | author = Goyert SM, Silver J | title = Further characterization of HLA DS molecules: implications for studies… …   Wikipedia

  • HLA-B17 — (B17) is an HLA B serotype. B17 is a broad antigen serotype that recognizes the B57 and B58 split antigen serotypes.cite journal | author = Marsh SG, Albert ED, Bodmer WF, et al | title = Nomenclature for factors of the HLA system, 2004 | journal …   Wikipedia

  • HLA-A — heteropolypeptide heteropolymer = MHC class I, A polymer type = heterodimer protein type = cell surface receptor function = Immune recognition and apoptosis image source = Illustration of HLA A | SubunitCount = 2 subunit1 = α gene1 =… …   Wikipedia

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