C4b

C4b
a constituent of the classical pathway C3 convertase (C4b,2a), generated by cleavage of C4 by C1s; the active fragment C4b then binds C2 for cleavage of C2 by C1s. It is inactivated by factor I in the presence of C4 binding protein. C4b is also an opsonin that binds to the same receptors as C3b.

Medical dictionary. 2011.

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