4-aminobutyrate transaminase
- 4-aminobutyrate transaminase
- 4-ami·no·bu·ty·rate trans·am·i·nase (ə-me″no-buґtə-rāt trans-amґĭ-nās) [EC 2.6.1.19] an enzyme of the transferase class that catalyzes the transfer of an amino group from γ-aminobutyrate (GABA) to α-ketoglutarate, forming glutamate and succinate semialdehyde. The reaction occurs predominantly in the liver and in the neurons of the brain. The enzyme can also act on β-alanine and β-aminoisobutyrate. Deficiency of the enzyme, an autosomal recessive trait, causes psychomotor retardation, hypotonia, hyperreflexia, and accelerated linear growth, with high levels of GABA, homocarnosine, and β-alanine in the cerebrospinal fluid. See also β-alanine–α-ketoglutarate transaminase. Called also GABA transaminase and aminobutyrate aminotransferase.
Medical dictionary.
2011.
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4-aminobutyrate transaminase — In enzymology, a 4 aminobutyrate transaminase (EC number|2.6.1.19) is an enzyme that catalyzes the chemical reaction:4 aminobutanoate + 2 oxoglutarate ightleftharpoons succinate semialdehyde + L glutamateThus, the two substrates of this enzyme… … Wikipedia
GABA transaminase — GABA trans·am·i·nase (gab″ə trans amґĭ nās) 1. 4 aminobutyrate transaminase. 2. a renal transaminase that catalyzes the transfer of an amino group from γ aminobutyrate (GABA) to pyruvate, forming alanine and succinate… … Medical dictionary
β-alanine–α-ketoglutarate transaminase — β al·a·nine–α ke·to·glu·ta·rate trans·am·i·nase (alґə nēn ke″to glooґtə rāt trans amґĭ nās) an enzyme activity that transfers the amino group from β alanine to α ketoglutarate, forming… … Medical dictionary
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