eosinophilic granuloma

eosinophilic granuloma
eosinophilic granuloma n a disease of adolescents and young adults marked by the formation of granulomas in bone and the presence in them of macrophages and eosinophilic cells with secondary deposition of cholesterol

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1. the mildest form of Langerhans cell histiocytosis, affecting primarily children, adolescents, and young adults. There may a single cranial lesion or a few foci, most often in the skull, spine, pelvis, ribs, or mandible and less commonly in the long bones, with localized pain and tenderness and sometimes pathologic fracture. 2. a disorder similar to eosinophilic gastroenteritis, characterized by localized nodular or pedunculated lesions of the submucosa and muscle walls, usually in the pyloric area of the stomach, but sometimes involving the small intestine. The cause is infiltration by eosinophils, but it does not involve peripheral eosinophilia or allergic symptoms. 3. anisakiasis in humans. 4. see eosinophilic granuloma complex, under complex.

Medical dictionary. 2011.

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