amphotericin B

amphotericin B
amphotericin B n the amphotericin that is clinically useful against deep-seated and systemic fungal infections

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am·pho·ter·i·cin B (am″fə-terґĭ-sin) [USP] one of two polyene antifungal antibiotics (the other, amphotericin A, is not used clinically), derived from a strain of Streptomyces nodosus and effective against a wide range of fungi and against some species of Leishmania. It is used intravenously or by intracavitary instillation in the treatment of progressive, potentially fatal fungal infections and as a secondary drug in the treatment of mucocutaneous leishmaniasis and topically in the treatment of superficial candidiasis.

Medical dictionary. 2011.

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  • Amphotericin B — Systematic (IUPAC) name (1R,3S,5R,6R,9 …   Wikipedia

  • amphotericin — amphotericin, amphotericin B amphotericin B . 1. an antibiotic and antifungal agent ({C47H73NO17}), produced by a strain of {Streptomyces nodosus}. It is one of a class of polyene macrolide antibiotics effective against fungal infections. It has… …   The Collaborative International Dictionary of English

  • amphotericin B — amphotericin amphotericin, amphotericin B amphotericin B . 1. an antibiotic and antifungal agent ({C47H73NO17}), produced by a strain of {Streptomyces nodosus}. It is one of a class of polyene macrolide antibiotics effective against fungal… …   The Collaborative International Dictionary of English

  • amphotericin B — [am΄fə ter′ə sin] n. 〚 AMPHOTERIC + IN1〛 an antibiotic compound, C46H73NO20, used in treating certain diseases caused by parasitic fungi, such as systemic candidiasis * * * …   Universalium

  • amphotericin B — [am΄fə ter′ə sin] n. [ AMPHOTERIC + IN1] an antibiotic compound, C46H73NO20, used in treating certain diseases caused by parasitic fungi, such as systemic candidiasis …   English World dictionary

  • Amphotericin B — Strukturformel Allgemeines Freiname Amphotericin B Andere Namen …   Deutsch Wikipedia

  • amphotericin B — (= Fungizone) Polyene antibiotic from Streptomyces spp. Used as a fungicide, it is cytolytic by causing the formation of pores (5 10 molecules of amphotericin in association with cholesterol) that allow passage of small molecules through the… …   Dictionary of molecular biology

  • amphotericin — am·pho·ter·i·cin .am(p) fə ter ə sən n either of two polyenic antifungal substances obtained from a soil bacterium of the genus Streptomyces (S. nodosus) esp AMPHOTERICIN B * * * n. an antifungal drug that is used to treat deep seated fungal… …   Medical dictionary

  • amphotericin B — noun : the amphotericin that is useful against deep seated and systemic fungal infections …   Useful english dictionary

  • amphotericin B cholesteryl complex — amphotericin B complexed with cholesteryl sulfate in a 1:1 ratio; administered by intravenous infusion in the treatment of disseminated aspergillosis in patients refractory to or intolerant of conventional amphotericin B therapy …   Medical dictionary

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