Reverse transcriptase

Reverse transcriptase
The enzyme that permits the human immunodeficiency virus (HIV) and other retroviruses to use their viral RNA as a template to make DNA. Reverse transcriptase is so-named because it reverses the usual transcription of DNA into RNA and lets RNA be transcribed into DNA.

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reverse transcriptase n a polymerase esp. of retroviruses that catalyzes the formation of DNA using RNA as a template

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an enzyme, found mainly in retrovirus, that catalyses the synthesis of DNA from RNA. It enables the viral RNA to be integrated into the host DNA. Reverse transcriptase inhibitors are antiviral drugs that inhibit this process; they include zidovudine and didanosine, used in the treatment of HIV infection, and lamivudine (Epivir, Zeffix), for treating HIV infection and hepatitis B.

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re·verse tran·scrip·tase (re-vursґ tran-skripґtās) RNA-directed DNA polymerase.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Reverse-transcriptase — Transcriptase inverse Transcriptase inverse Général Synonymes EC …   Wikipédia en Français

  • Reverse transcriptase — Transcriptase inverse Transcriptase inverse Général Synonymes EC …   Wikipédia en Français

  • reverse transcriptase — n. an enzyme that makes DNA from RNA, found in retroviruses and widely used in recombinant DNA technology: cf. TRANSCRIPTASE …   English World dictionary

  • reverse transcriptase — reverse transcriptase. См. ревертаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Reverse transcriptase — Protbox Name=Reverse Transcriptase Photo=1HMV.png|250px Caption=3D model of HIV reverse transcriptase HGNCid = Symbol = AltSymbols = Chromosome = Arm = Band = LocusSupplementaryData = Gene= Gene type= Protein length= Molecular weight= Structure=… …   Wikipedia

  • reverse transcriptase — an enzyme, found mainly in retroviruses, that catalyses the synthesis of DNA from RNA. It enables the viral RNA to be integrated into the host DNA. Reverse transcriptase inhibitors are antiviral drugs that inhibit this process; they include… …   The new mediacal dictionary

  • Reverse-transcriptase inhibitor — Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors,[1] and cancer.[2] RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce.… …   Wikipedia

  • Reverse transcriptase inhibitor — Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors [ [http://jcem.endojournals.org/cgi/content/full/90/10/5663/F1 Reverse Transcriptase Inhibitors Down Regulate Cell Proliferation in… …   Wikipedia

  • Reverse transcriptase PCR — Reverse Transcriptase Polymerase Chain Reaction, abbreviated as RT PCR , is a two step process for converting RNA to DNA subsequent PCR amplification of the reversely transcribed DNA:1. first strand reaction::Complementary DNA (cDNA) is made from …   Wikipedia

  • reverse transcriptase inhibitor — n an agent that inhibits the activity of a reverse transcriptase esp a drug (as AZT) that acts by inhibiting retroviral reverse transcription * * * a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an… …   Medical dictionary

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