Antibody-dependent cell-mediated cytotoxicity
- Antibody-dependent cell-mediated cytotoxicity
- An immune response in which antibody, by coating target cells, makes them vulnerable to attack by immune cells. Antibody-dependent cell-mediated cytotoxicity is commonly (and blissfully) abbreviated ADCC.
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(ADCC), antibody-dependent cellular cytotoxicity lysis of target cells coated with antibody by effector cells with cytolytic activity and Fc receptors, including K cells, macrophages, and granulocytes; a form of type II hypersensitivity reaction. ADCC involves binding of the effector cell by means of Fc receptors which bind to the Fc portion of the IgG molecule. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
Medical dictionary.
2011.
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ADCC — Antibody dependent cell mediated cytotoxicity, an immune response in which antibody, by coating target cells, makes them vulnerable to attack by immune cells. Antibody dependent cell mediated cytotoxicity is commonly (and blissfully) abbreviated… … Medical dictionary
