thromboxane

thromboxane
The formal parent of the thromboxanes; prostanoic acid in which the –COOH has been reduced to –CH3 and an oxygen atom has been inserted between carbons 11 and 12.

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throm·box·ane thräm-'bäk-.sān n any of several substances that are produced esp. by platelets, are formed from endoperoxides, cause constriction of vascular and bronchial smooth muscle, and promote blood clotting

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throm·box·ane (throm-bokґsān) [thrombocyte + oxane ring] either of two compounds related to prostaglandins and derived from arachidonic acid. Thromboxane A2 (TXA2) is an extremely potent inducer of platelet aggregation and platelet release reactions and is also a vasoconstrictor; it is thus a physiologic antagonist of prostacyclin. It is synthesized by platelets and is very unstable, with a half-life of 30 seconds, undergoing nonenzymatic hydrolysis to thromboxane B2 (TXB2), which is inactive.

Medical dictionary. 2011.

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  • Thromboxane — is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2.Thromboxane is named for its role in clot formation (thrombosis).ProductionIt is produced in platelets by thromboxane A… …   Wikipedia

  • Thromboxane — A2 Les thromboxanes sont des hormones à effet vasoconstricteurs. Elles engendrent une augmentation de la pression artérielle. Elles activent aussi l agrégation des plaquettes et aident à la coagulation sanguine et au thrombus ou caillot sanguin d …   Wikipédia en Français

  • thromboxane — [thrämbäk′sān] n. [ THROMB(O) + OX(Y) + ANE] any of various derivatives of prostaglandins, which form on blood platelets and, usually, cause blood clots and constrict blood vessels: Cf. PROSTACYCLIN …   English World dictionary

  • Thromboxane A2 — Chembox new ImageFile = Thromboxane A2 acsv.svg ImageSize = IUPACName = OtherNames = Section1 = Chembox Identifiers CASNo = 57576 52 0 PubChem = 5280497 SMILES = MeSHName = Thromboxane+A2 Section2 = Chembox Properties Formula =… …   Wikipedia

  • Thromboxane B2 — Chembox new ImageFile=Thromboxane B2.svg ImageSize=250px IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=54397 85 2 PubChem=5283137 SMILES= MeSHName=Thromboxane+B2 Section2= Chembox Properties Formula=C20H34O6 MolarMass=370.48 g/mol… …   Wikipedia

  • Thromboxane-A synthase — 1 (platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a human gene.cite web | title = Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)| url =… …   Wikipedia

  • Thromboxane receptor — The thromboxane receptor is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G protein coupled receptors coupled to the G protein Gq.cite… …   Wikipedia

  • thromboxane-A synthase — throm·box·ane A syn·thase (throm bokґsān sinґthās) [EC 5.3.99.5] an enzyme of the isomerase class that catalyzes the conversion in platelets of prostaglandin G2 to thromboxane A2, a potent vasoconstrictor and platelet agonist. Deficient …   Medical dictionary

  • thromboxane — noun Etymology: thromb + ox + ane Date: 1975 any of several substances that are produced especially by platelets, are formed from endoperoxides, cause construction of vascular and bronchial smooth muscle, and promote blood clotting …   New Collegiate Dictionary

  • thromboxane — /throm bok sayn/, n. Biochem. a compound, C20H32O5, formed in blood platelets, that constricts blood vessels and promotes clotting. [1935 40; THROMB + OX + ANE] * * * …   Universalium

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