Hemophilia

Hemophilia
A set of inherited bleeding disorders in which the ability of blood to clot is impaired.
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An inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhages, spontaneous or traumatic, because of a defect in the blood coagulating mechanism. [hemo- + G. philos, fond]
- h. A [MIM*306700-various] h. due to deficiency of factor VIII; an X-linked recessive condition, occurring almost exclusively in human males and also affecting several breeds of dogs, characterized by prolonged clotting time, decreased formation of thromboplastin, and diminished conversion of prothrombin. SYN: classic h..
- h. B [MIM*306900-various] a clotting disorder resembling h. A, caused by hereditary deficiency of factor IX; also seen as an X-linked recessive condition in the Cairn terrier breed of dogs. SYN: Christmas disease.
- h. C h. due to deficiency of factor XI; clinically resembles h. A and B but is transmitted as an autosomal dominant inheritance; occurs primarily in persons of Jewish ancestry.
- classic h. SYN: h. A.

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he·mo·phil·ia or chiefly Brit hae·mo·phil·ia .hē-mə-'fil-ē-ə n a sex-linked hereditary blood defect that occurs almost exclusively in males and is characterized by delayed clotting of the blood and consequent difficulty in controlling hemorrhage even after minor injuries compare CHRISTMAS DISEASE, HEMORRHAGIC DIATHESIS

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he·mo·phil·ia (he″mo-filґe-ə) [hemo- + -philia] a hemorrhagic diathesis occurring in two main forms, designated hemophilia A and hemophilia B. Both are determined by a mutant gene near the telomere of the long arm of the X chromosome, but at different loci, and are characterized by subcutaneous and intramuscular hemorrhages; bleeding from the mouth, gums, lips, and tongue; hematuria; and hemarthroses.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Hemophilia B — Hemophilia due to deficiency of coagulation factor IX in the blood which results in prolonged oozing after minor and major injuries, tooth extractions, or surgery. There is renewed bleeding after the initial bleeding has stopped. The gene for… …   Medical dictionary

  • Hemophilia — Hem o*phil i*a (h[=e] m[.a]*f[i^]l [i^]*[.a] or h[e^]m [.a]*f[i^]l [i^]*[.a]), n. [NL., fr. Gr. a i^ma, blood + filei^n to love.] (Med.) A condition characterized by a tendency to profuse and uncontrollable hemorrhage from the slightest wounds;… …   The Collaborative International Dictionary of English

  • hemophilia A — hemophilia A. См. гемофилия А. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemophilia B — hemophilia B. См. гемофилия В. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemophilia C — hemophilia C. См. гемофилия С. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemophilia — 1854 (in anglicized form hæmophily), from Ger. hämophile, coined 1828 by German physician Johann Lucas Schönlein (1793 1864), from Gk. haima blood (see EMIA (Cf. emia)) + philia to love (see PHILIA (Cf. philia)), here with a sense of tendency to …   Etymology dictionary

  • hemophilia — [hē΄məfil′ē ə, hē΄məfē′lē ə] n. [ModL: see HEMO & PHILIA] any of several hereditary disorders, nearly always of males, in which one of the normal blood clotting factors is deficient, causing serious internal or external hemorrhage from minor cuts …   English World dictionary

  • hemophilia — /hee meuh fil ee euh, feel yeuh, hem euh /, n. any of several X linked genetic disorders, symptomatic chiefly in males, in which excessive bleeding occurs owing to the absence or abnormality of a clotting factor in the blood. [1850 55; < NL; see… …   Universalium

  • Hemophilia A — Classic hemophilia due to profound deficiency of factor VIII in the blood, which is necessary for normal clotting. The hemophilia A gene is on the X chromosome, so females carry the gene. Each son of a female carrier stands a 50 percent chance of …   Medical dictionary

  • hemophilia — noun congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son • Syn: ↑haemophilia, ↑bleeder s disease • Derivationally related forms: ↑haemophilic (for: ↑haemophilia) …   Useful english dictionary

  • hemophilia — Synonyms and related words: Christmas disease, Hand Schuller Christian disease, Hartnup disease, Letterer Siwe syndrome, Werdnig Hoffmann disease, achromatic vision, acute leukemia, albinism, anemia, angiohemophilia, aplastic anemia, chronic… …   Moby Thesaurus

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