Hemophilia B

Hemophilia B
Hemophilia due to deficiency of coagulation factor IX in the blood which results in prolonged oozing after minor and major injuries, tooth extractions, or surgery. There is renewed bleeding after the initial bleeding has stopped. The gene for hemophilia B gene is on the X chromosome, so males are affected and females carry the gene. About 10% of carrier females are at risk for bleeding. Each son of a female carrier stands a 50 percent chance of receiving the gene and having hemophilia B. Treatment is by blood products that introduce clotting factor IX and replace lost blood. Hemophilia B is also called Christmas disease (so-named for the first patient studied in detail with the disease).

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hemophilia B n CHRISTMAS DISEASE

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an X-linked recessive condition, clinically indistinguishable from hemophilia A, caused by mutation in the coagulation factor IX gene (F9, locus: Xq27.1-q27.2) that results in deficiency of the factor. Called also Christmas disease.

Medical dictionary. 2011.

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  • Hemophilia — Hem o*phil i*a (h[=e] m[.a]*f[i^]l [i^]*[.a] or h[e^]m [.a]*f[i^]l [i^]*[.a]), n. [NL., fr. Gr. a i^ma, blood + filei^n to love.] (Med.) A condition characterized by a tendency to profuse and uncontrollable hemorrhage from the slightest wounds;… …   The Collaborative International Dictionary of English

  • hemophilia A — hemophilia A. См. гемофилия А. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemophilia B — hemophilia B. См. гемофилия В. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemophilia C — hemophilia C. См. гемофилия С. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemophilia — 1854 (in anglicized form hæmophily), from Ger. hämophile, coined 1828 by German physician Johann Lucas Schönlein (1793 1864), from Gk. haima blood (see EMIA (Cf. emia)) + philia to love (see PHILIA (Cf. philia)), here with a sense of tendency to …   Etymology dictionary

  • hemophilia — [hē΄məfil′ē ə, hē΄məfē′lē ə] n. [ModL: see HEMO & PHILIA] any of several hereditary disorders, nearly always of males, in which one of the normal blood clotting factors is deficient, causing serious internal or external hemorrhage from minor cuts …   English World dictionary

  • hemophilia — /hee meuh fil ee euh, feel yeuh, hem euh /, n. any of several X linked genetic disorders, symptomatic chiefly in males, in which excessive bleeding occurs owing to the absence or abnormality of a clotting factor in the blood. [1850 55; < NL; see… …   Universalium

  • Hemophilia A — Classic hemophilia due to profound deficiency of factor VIII in the blood, which is necessary for normal clotting. The hemophilia A gene is on the X chromosome, so females carry the gene. Each son of a female carrier stands a 50 percent chance of …   Medical dictionary

  • hemophilia — noun congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son • Syn: ↑haemophilia, ↑bleeder s disease • Derivationally related forms: ↑haemophilic (for: ↑haemophilia) …   Useful english dictionary

  • hemophilia — Synonyms and related words: Christmas disease, Hand Schuller Christian disease, Hartnup disease, Letterer Siwe syndrome, Werdnig Hoffmann disease, achromatic vision, acute leukemia, albinism, anemia, angiohemophilia, aplastic anemia, chronic… …   Moby Thesaurus

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