Failure of proper or normal development; more specifically, a primary structural defect that results from a localized error of morphogenesis; e.g., cleft lip. Cf.:deformation.
- Arnold-Chiari m. malformed posterior fossa structures associated with caudad traction and displacement of the rhombencephalon as caused by tethering of the spinal cord; may or may not be accompanied by spina bifida and associated anomalies such as meningomyelocele; this m. is usually multifactorial in inheritance; very weak evidence of autosomal recessive inheritance [MIM*207950]. SYN: Arnold-Chiari deformity, Arnold-Chiari syndrome, cerebellomedullary m. syndrome.
- cystic adenomatoid m. a rare developmental lung-bud abnormality which results in stillbirth, acute progressive respiratory disease of newborns, or protracted childhood pneumonias; this m. combines features of a hamartoma, dysplastic growth, and tumorous growth. Three types have been described, based chiefly on cyst diameters: Type I: up to 10 cm; Type II: less than 1.2 cm; Type III: less than 0.5 cm.
- mermaid m. SYN: sirenomelia.
- Michel m. hypoplasia of the petrous pyramid and aplasia of the inner ear.
- venous m. SYN: venous angioma.

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mal·for·ma·tion .mal-fȯr-'mā-shən, -fər- n irregular, anomalous, abnormal, or faulty formation or structure <congenital \malformations>

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any variation from the normal physical structure, due either to congenital or developmental defects or to disease or injury.

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mal·for·ma·tion (mal″for-maґshən) [L. malus evil + formation] 1. a type of anomaly. 2. a morphologic defect of an organ or larger region of the body, resulting from an intrinsically abnormal developmental process.

Medical dictionary. 2011.

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  • malformation — [ malfɔrmasjɔ̃ ] n. f. • 1867; de 1. mal et formation ♦ Vice de conformation congénital (alors que les déformations sont en général acquises). ⇒ difformité, dystrophie, infirmité. Naître avec une malformation cardiaque. Malformation congénitale… …   Encyclopédie Universelle

  • Malformation — Mal for*ma tion, n. [Mal + formation.] Ill formation; irregular or anomalous formation; abnormal or wrong conformation or structure; often used of body parts such as limbs which do not develop properly during fetal maturation. [1913 Webster +PJC] …   The Collaborative International Dictionary of English

  • malformation — malformation. См. тератоморфа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • malformation — index irregularity Burton s Legal Thesaurus. William C. Burton. 2006 …   Law dictionary

  • malformation — also mal formation, 1731, from MAL (Cf. mal ) + FORMATION (Cf. formation) …   Etymology dictionary

  • malformation — [n] deformity abberation, abnormality, defect, disfigurement, impairment, injury, malconformation, misshape, monstrosity, mutation; concept 580 …   New thesaurus

  • malformation — ► NOUN ▪ abnormality of shape or form in a part of the body. DERIVATIVES malformed adjective …   English terms dictionary

  • malformation — [mal΄fôr mā′shən] n. faulty, irregular, or abnormal formation or structure of a body or part malformed [mal′fôrmd′] adj …   English World dictionary

  • Malformation — Radiographie d une main polydactyle post axiale …   Wikipédia en Français

  • malformation — /mal fawr may sheuhn, feuhr /, n. faulty or anomalous formation or structure, esp. in a living body: malformation of the teeth. [1790 1800; MAL + FORMATION] * * * ▪ biology Introduction       in biology, irregular or abnormal structural… …   Universalium

  • malformation — n. a congenital malformation * * * [ˌmælfɔː meɪʃ(ə)n] a congenital malformation …   Combinatory dictionary

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