isosorbide dinitrate

A coronary vasodilator that acts via the formation of nitric oxide.

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iso·sor·bide di·ni·trate -dī-'nī-.trāt n a coronary vasodilator C₆H₈N₂O₈ used esp. in the treatment of angina pectoris see ISORDIL

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a drug used for the treatment of angina; it acts by relaxing the smooth muscle of both arteries and veins, thus causing dilatation (see vasodilator). It is administered by mouth (as tablets that are swallowed or dissolve under the tongue), as a spray (under the tongue or on the skin) or by injection; side-effects include headache, flushing, dizziness, and hypotension. Trade names: Angitak, Cedocard, Isocard, Isoket, <.

Isosorbide dinitrate is converted in the body to the active form of the drug, isosorbide mononitrate, which is also available as a treatment for angina. Trade names: Elantan, Imdur, Isodur, Isotard, Monit, etc.

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[USP] the dinitric acid ester of isosorbide, having coronary and peripheral vasodilating properties; used in the treatment of coronary insufficiency and angina pectoris, administered sublingually and orally.