glyoxalase

glyoxalase
An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in red cells and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acid s (g. II) or glyoxals (g. I).

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gly·ox·a·lase -sə-.lās, -.lāz n an enzyme that accelerates reversibly the conversion in the presence of glutathione of methylglyoxal to lactic acid

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gly·ox·a·lase (gli-okґsə-lās) a term used to describe the enzyme activity that converts methylglyoxal to lactic acid. It is composed of two enzymes: lactoylglutathione lyase (glyoxalase I) and hydroxyacylglutathione hydrolase (glyoxalase II).

Medical dictionary. 2011.

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  • glyoxalase — noun Either of a pair of related thiol dependent enzymes: glyoxalase І, which catalyses the isomerisation of the spontaneously formed hemithioacetal adduct between GSH and 2 oxoaldehydes (such as methylglyoxal) into S 2 hydroxyacylglutathione;… …   Wiktionary

  • Glyoxalase system — The glyoxalase system is a set of enzymes that carry out the detoxification of methylglyoxal and the other reactive aldehydes that are produced as a normal part of metabolism. [Vander Jagt, D. (1989). The glyoxalase system . In Glutathione:… …   Wikipedia

  • glyoxalase — gly·ox·a·lase …   English syllables

  • glyoxalase — glīˈäksəˌlās, āz noun ( s) Etymology: glyoxal + ase : an enzyme that accelerates reversibly the conversion in the presence of glutathione of pyruvaldehyde to lactic acid …   Useful english dictionary

  • Système glyoxalase — Le système glyoxalase est une série d enzymes prenant en charge la détoxification du méthylglyoxal et d autres espèces réactives d aldéhydes produites pendant les différentes étapes du métabolisme[1]. Ce système a déjà été étudié chez les… …   Wikipédia en Français

  • GLO1 — Glyoxalase I, also known as GLO1, is a human gene.cite web | title = Entrez Gene: GLO1 glyoxalase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2739| accessdate = ] It is a Lactoylglutathione lyase. PBB …   Wikipedia

  • lactoylglutathione lyase — Glyoxalase I; a lyase cleaving S d lactoylglutathione to glutathione and methylglyoxal. SYN: aldoketomutase, ketone aldehyde mutase, methylglyoxalase. * * * lac·to·yl·glu·ta·thi·one ly·ase (lak″to əl gloo″tə thiґōn… …   Medical dictionary

  • GLO I — (glyoxalase I)    A protein marker found in the blood and other body fluids …   Forensic science glossary

  • Lactoylglutathione lyase — Identifiers EC number 4.4.1.5 CAS number 9033 12 9 …   Wikipedia

  • HAGH — Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.cite web | title = Entrez Gene: HAGH hydroxyacylglutathione hydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3029| accessdate …   Wikipedia

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