An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in red cells and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acid s (g. II) or glyoxals (g. I).

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gly·ox·a·lase -sə-.lās, -.lāz n an enzyme that accelerates reversibly the conversion in the presence of glutathione of methylglyoxal to lactic acid

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gly·ox·a·lase (gli-okґsə-lās) a term used to describe the enzyme activity that converts methylglyoxal to lactic acid. It is composed of two enzymes: lactoylglutathione lyase (glyoxalase I) and hydroxyacylglutathione hydrolase (glyoxalase II).

Medical dictionary. 2011.

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  • glyoxalase — noun Either of a pair of related thiol dependent enzymes: glyoxalase І, which catalyses the isomerisation of the spontaneously formed hemithioacetal adduct between GSH and 2 oxoaldehydes (such as methylglyoxal) into S 2 hydroxyacylglutathione;… …   Wiktionary

  • Glyoxalase system — The glyoxalase system is a set of enzymes that carry out the detoxification of methylglyoxal and the other reactive aldehydes that are produced as a normal part of metabolism. [Vander Jagt, D. (1989). The glyoxalase system . In Glutathione:… …   Wikipedia

  • glyoxalase — gly·ox·a·lase …   English syllables

  • glyoxalase — glīˈäksəˌlās, āz noun ( s) Etymology: glyoxal + ase : an enzyme that accelerates reversibly the conversion in the presence of glutathione of pyruvaldehyde to lactic acid …   Useful english dictionary

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  • GLO1 — Glyoxalase I, also known as GLO1, is a human gene.cite web | title = Entrez Gene: GLO1 glyoxalase I| url = Cmd=ShowDetailView TermToSearch=2739| accessdate = ] It is a Lactoylglutathione lyase. PBB …   Wikipedia

  • lactoylglutathione lyase — Glyoxalase I; a lyase cleaving S d lactoylglutathione to glutathione and methylglyoxal. SYN: aldoketomutase, ketone aldehyde mutase, methylglyoxalase. * * * lac·to·yl·glu·ta·thi·one ly·ase (lak″to əl gloo″tə thiґōn… …   Medical dictionary

  • GLO I — (glyoxalase I)    A protein marker found in the blood and other body fluids …   Forensic science glossary

  • Lactoylglutathione lyase — Identifiers EC number CAS number 9033 12 9 …   Wikipedia

  • HAGH — Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.cite web | title = Entrez Gene: HAGH hydroxyacylglutathione hydrolase| url = Cmd=ShowDetailView TermToSearch=3029| accessdate …   Wikipedia

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