cooperativity

cooperativity
A property of certain proteins (often enzymes) in which the binding curves or saturation curves or, in the case of enzymes, a plot of initial rates as a function of initial substrate concentration, are nonhyperbolic; suggests that the binding of a ligand has a different affinity at different ligand concentrations. Both allosterism and hysteresis are models that will display c.. Cf.:allosterism, hysteresis.
- negative c. c. in which successive ligand molecules appear to bind with decreasing affinity.
- positive c. c. in which successive ligand molecules appear to bind with increasing affinity.

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co·op·er·a·tiv·i·ty (ko-op″ər-ə-tivґĭ-te) the phenomenon of alteration of binding of subsequent ligands upon binding of an initial ligand by an enzyme, receptor, or other molecule with multiple binding sites, such as frequently occurs in enzymes exhibiting allostery.

Medical dictionary. 2011.

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  • cooperativity — /koh op euhr euh tiv i tee/, n. Biochem. the increase or decrease in the rate of interaction between a reactant and a protein as the reactant concentration increases. Also, co operativity. [COOPERATIVE + ITY] * * * ▪ enzymology       in… …   Universalium

  • Cooperativity — …   Википедия

  • cooperativity — noun An interaction between the substrate binding sites of an allosteric enzyme in which binding at one site increases or decreases binding at another …   Wiktionary

  • cooperativity — /koh op euhr euh tiv i tee/, n. Biochem. the increase or decrease in the rate of interaction between a reactant and a protein as the reactant concentration increases. Also, co operativity. [COOPERATIVE + ITY] …   Useful english dictionary

  • negative cooperativity — cooperativity in which the dissociation constant for each successive ligand bound is higher than for the one preceding it, so that the binding affinity is successively decreased …   Medical dictionary

  • positive cooperativity — cooperativity in which the dissociation constant for each successive ligand bound is lower than for the one preceding it, so that the binding affinity is successively increased …   Medical dictionary

  • Cooperative binding — In biochemistry, a macromolecule exhibits cooperative binding if its affinity for its ligand changes with the amount of ligand already bound. Cooperative binding is a special case of allostery. Cooperative binding requires that the macromolecule… …   Wikipedia

  • Enzyme kinetics — is the study of the chemical reactions that are catalysed by enzymes, with a focus on their reaction rates. The study of an enzyme s kinetics reveals the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled,… …   Wikipedia

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