ubiquitin-proteasome system

ubiquitin-proteasome system
a mechanism regulating receptor-mediated endocytosis of selected membrane proteins, involving ubiquitination of targeted proteins followed by their attachment to the proteasome and subsequent internalization and degradation.

Medical dictionary. 2011.

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  • Ubiquitin — is a highly conserved regulatory protein that is expressed in eukaryotes. Ubiquitination (or ubiquitylation) refers to the post translational modification of a protein by the covalent attachment (via an isopeptide bond) of one or more ubiquitin… …   Wikipedia

  • Ubiquitin — Bändermodell …   Deutsch Wikipedia

  • Proteasome — Protéasome Représentation du protéasome obtenue par Diffractométrie de rayons X après cristalisation. Le cœur catalytique 20S est en bleu. Les deux complexes régulateurs 11S sont en rouge. Les protéasomes sont des complexes enzymatiques… …   Wikipédia en Français

  • Ubiquitin-conjugating enzyme — Ubiquitin conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin carrier enzymes , perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process… …   Wikipedia

  • Proteasome — Proteasomes are large protein complexes inside all eukaryotes and archaea, as well as in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm.cite journal |author=Peters JM, Franke WW, Kleinschmidt JA |title=Distinct 19 …   Wikipedia

  • Protéasome — Représentation du protéasome obtenue par Diffractométrie de rayons X après cristalisation. Le cœur catalytique 20S est en bleu. Les deux complexes régulateurs 11S sont en rouge. Les protéasomes sont des complexes enzymatiques multiprotéiques que… …   Wikipédia en Français

  • proteasome inhibitors — a class of antineoplastic agents that disrupt the ubiquitin proteasome system of cells, thereby interfering with growth and other cellular processes …   Medical dictionary

  • Ubiquitin ligase — A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that covalently attaches ubiquitin to a lysine on a target protein via an isopeptide bond. In general, the ubiquitin ligase is involved in polyubiquitination: A second ubiquitin …   Wikipedia

  • Ubiquitin carboxy-terminal hydrolase L1 — (UCH L1) (EC number|3.1.2.15) is a deubiqutinating enzyme. PBB Summary section title = summary text = UCHL1 is a member of a gene family whose products hydrolyze small C terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression… …   Wikipedia

  • Ubiquitinierung — Ubiquitin Bändermodell Größe …   Deutsch Wikipedia

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