type III

type III
local or general inflammatory response due to formation of circulating antigen-antibody complexes and their deposition in tissues; the complexes activate complement and other inflammatory mediators, initiating processes including increased vascular permeability, stimulation of mast cell degranulation and neutrophil chemotaxis and accumulation, and aggregation of platelets, and resulting in tissue damage. Ensuing diseases, called also immune complex diseases, can be roughly classified as being due to persistent infection, to autoimmunity, or to inhalation of antigenic material; examples include serum sickness, Arthus reaction, subacute bacterial endocarditis, systemic lupus erythematosus, and farmer's lung. Called also immune complex–mediated hypersensitivity r.

Medical dictionary. 2011.

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