type II

type II
tissue or cell damage resulting from the interaction of antibodies and antigens on cell surfaces; specific IgG or IgM against cell surface or extracellular matrix antigens or cell surface receptors binds and causes damage at the site of binding by any of several mechanisms involving either complement activation and lysis or opsonization mediated by receptors for Fc or C3b, leading to phagocytosis and destruction by macrophages and neutrophils. Examples of disorders caused by such tissue damage include myasthenia gravis, hemolytic anemia, Goodpasture syndrome, and Rh incompatibility and transfusion reactions. Called also antibody-mediated hypersensitivity r. and cytotoxic hypersensitivity r.

Medical dictionary. 2011.

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