endogenous pyrogen

endogenous pyrogen
fever-producing subtances produced by the macrophages or other cells in response to infection or to events inducing cell-mediated immunity; included are interleukin-1 and tumor necrosis factor.

Medical dictionary. 2011.

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  • endogenous pyrogen — (en doj e nus pi ro jen) A substance such as the lymphokine interleukin 1, which is produced by host cells and induces a fever response in the host. It also is called simply a pyrogen …   Dictionary of microbiology

  • endogenous pyrogen — Fever producing substance released by leucocytes (and Kuppfer cells in particular) that acts on the hypothalamic thermoregulatory centre. Now known to be interleukin 1 …   Dictionary of molecular biology

  • pyrogen — Substance or agent that produces fever. The major endogenous pyrogen in mammals is probably interleukin 1 …   Dictionary of molecular biology

  • pyrogen — A fever inducing agent; pyrogens are produced by bacteria, molds, viruses, and yeasts. [pyro + G. gen, producing] endogenous p. (EP) proteins that induce fever. Several (about 11) have been identified, including cytokines formed by components of… …   Medical dictionary

  • exogenous pyrogen — a fever producing agent of external origin; types include bacterial endotoxins and other microbial products, certain types of antigen antibody complexes, viruses, synthetic polynucleotides, incompatible blood and blood products, and androgen… …   Medical dictionary

  • Interleukin 1 — protein Name = interleukin 1, alpha caption = Crystal structure of IL 1a (PDB|2ILA). width = 250 HGNCid = 5991 Symbol = IL1A AltSymbols = IL1; IL 1A; IL1; IL1 ALPHA; IL1F1 EntrezGene = 3552 OMIM = 147760 RefSeq = NM 000575 UniProt = P01583 PDB =… …   Wikipedia

  • EP — Abbreviation for endogenous pyrogen. * * * echo planar; ectopic pregnancy; edible portion; electronic palpation; electrophoresis; electrophysiologic; electroprecipitin; emergency physician; emergency procedure; endocochlear potential; endogenous… …   Medical dictionary

  • interleukin-1 — (= IL 1) Protein (17 kD: 152 amino acids) secreted by macrophages or accessory cells involved in the activation of both T and B lymphocytes in response to antigens or mitogens, as well as affecting a wide range of other cell types. At least two… …   Dictionary of molecular biology

  • Drug-induced fever — is a state wherein the administration of drugs intended to help a patient causes a fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous… …   Wikipedia

  • lipopolysaccharide — The major constituents of the cell walls of Gram negative bacteria. Highly immunogenic and stimulates the production of endogenous pyrogen interleukin 1 and tumour necrosis factor (TNF) …   Dictionary of molecular biology

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