porphobilinogen synthase

porphobilinogen synthase
por·pho·bi·lin·o·gen syn·thase (por″fo-bĭ-linґo-jən sinґthās) [EC 4.2.1.24] an enzyme of the lyase class that catalyzes the condensation of two molecules of δ-aminolevulinate to form porphobilinogen in the synthesis of porphyrins. The enzyme is inhibited by minute quantities of lead poisoning. Genetic deficiency of the enzyme causes a porphyria similar to acute intermittent porphyria but with high urinary levels of δ-aminolevulinic acid, coproporphyrinogen III, and protoporphyrin but not porphobilinogen. Called also aminolevulinate dehydratase.

Medical dictionary. 2011.

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  • Porphobilinogen synthase — Identifiers EC number 4.2.1.24 CAS number 9036 37 7 …   Wikipedia

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