phosphorylase kinase

phosphorylase kinase
phos·phor·y·lase ki·nase (fos-forґə-lās kiґnās) [EC 2.7.11.19] an enzyme of the transferase class that catalyzes the phosphorylation of (inactive) glycogen phosphorylase b to form (active) glycogen phosphorylase a, a step in the cascade of reactions regulating glycogenolysis. The enzyme is itself activated via phosphorylation by cyclic-AMP–dependent protein kinase. There are liver and muscle isoforms, each of which comprises four subunits, alpha, beta, gamma, and delta, encoded by multiple genes on multiple chromosomes; the alpha and gamma subunits are differentially encoded and expressed in different tissues while the beta remains constant across the isoforms and the delta is calmodulin. Deficiency of the enzyme causes glycogen storage disease, type IX (q.v.), which is divided into subtypes on the basis of which isoform and specific subunit the mutation affects. Written also phosphorylase b kinase.

Medical dictionary. 2011.

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  • Phosphorylase-Kinase — Masse/Länge Primärstruktur 10996 = 4*(1223+1092+386+148) Aminosäuren …   Deutsch Wikipedia

  • Phosphorylase kinase — is a serine/threonine specific protein kinase which converts glycogen phosphorylase b to glycogen phosphorylase a, activating it to release glucose 1 phosphate from glycogen.Genes* Alpha: PHKA1, PHKA2 * Beta: PHKB * Gamma: PHKG1,… …   Wikipedia

  • phosphorylase kinase — phosphorylase kinase. См. киназа фосфорилазы. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • phosphorylase kinase — The enzyme that regulates the activity of phosphorylase and glycogen synthetase by addition of phosphate groups. A large and complex enzyme, itself regulated by phosphorylation. Integrates the hormonal and calcium signals in muscle …   Dictionary of molecular biology

  • glycogen phosphorylase kinase — gly·co·gen phos·phor·y·lase ki·nase (gliґko jən fos forґə lās kiґnās) phosphorylase kinase …   Medical dictionary

  • hepatic phosphorylase kinase — he·pat·ic phos·phor·y·lase ki·nase (hə patґik fos forґə lās kiґnās) the liver isozyme of phosphorylase kinase …   Medical dictionary

  • liver phosphorylase kinase — liv·er phos·phor·y·lase ki·nase (livґər fos forґə lās kiґnās) the liver isozyme of phosphorylase kinase …   Medical dictionary

  • kinase — [ kinaz ] n. f. • 1902; du gr. kinein « mettre en mouvement » et ase ♦ Biochim. Enzyme capable d activer par phosphorylation un métabolite, un autre enzyme (phosphorylase kinase) ou une protéine impliquée dans la réponse cellulaire à certains… …   Encyclopédie Universelle

  • phosphorylase — (= glycogen phosphorylase) Enzyme that catalyses the sequential removal of glycosyl residues from glycogen to yield one glucose 1 phosphate per reaction. Its activity is controlled by phosphorylation (by phosphorylase kinase) …   Dictionary of molecular biology

  • Phosphorylase — is a family of allosteric enzymes that catalyze the production of glucose 1 phosphate from a polyglucose such as glycogen, starch or maltodextrin.FunctionMore generally, phosphorylases are enzymes that catalyze the addition of a phosphate group… …   Wikipedia

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