phosphoinositide phospholipase C

phosphoinositide phospholipase C
phos·pho·ino·si·tide phos·pho·lip·ase C (fos″fo-in-oґsĭ-tīd fos″fo-lipґās) [EC 3.1.4.11] an enzyme of the hydrolase class that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate inositol 1,4,5-triphosphate and diacylglycerol, second messengers that initiate a cascade of intracellular responses resulting in cell growth and differentiation and gene expression. The enzyme can also act on phosphatidylinositol, carrying out the reaction formerly ascribed to the enzyme officially called 1-phosphatidylinositol phosphodiesterase (q.v.). See also phospholipase C.

Medical dictionary. 2011.

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  • Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français

  • EC 3.1 — Le groupe EC3.1 est un groupe d hydrolases rassemblant les estérases, c est à dire les enzymes catalysant la réaction générale : R O R + H2O ⇌ R OH + R OH où R représente un acide quelconque et R son substrat. En fonction du milieu, l ester… …   Wikipédia en Français

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