orotate phosphoribosyltransferase

orotate phosphoribosyltransferase
(OPRT) or·o·tate phos·pho·ri·bo·syl·trans·fer·ase (OPRT) (orґo-tāt fos″fo-ri″bo-səl-transґfər-ās) [EC] an enzyme activity of the transferase class that catalyzes the transfer to orotate of a ribosyl group from phosphoribosylpyrophosphate (PRPP) to form orotidine 5′-phosphate as a step in the synthesis of pyrimidine nucleotides. The catalytic sites for this activity and for orotidine 5′-phosphate decarboxylase (ODC) activity occur on a single protein, called UMP synthase; deficiency of both activities, an autosomal recessive trait, results in hereditary oroticaciduria, type I.

Medical dictionary. 2011.

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