systemic mastocytosis

systemic mastocytosis
a condition in which there are mast cell infiltrates in noncutaneous tissues, with or without cutaneous lesions; the most common sites are the liver, spleen, bone, lymph nodes, and gastrointestinal tract. See also mastocytosis syndrome, under syndrome.

Medical dictionary. 2011.

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  • systemic mastocytosis — A rare disease in which too many mast cells (a type of immune system cell) are found in the skin, bones, joints, lymph nodes, liver, spleen, and gastrointestinal tract. Mast cells give off chemicals such as histamine that can cause flushing (a… …   English dictionary of cancer terms

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  • mastocytosis syndrome — an episodic syndrome occurring in certain patients with systemic mastocytosis, usually those with skin lesions, bone lesions, and hepatosplenomegaly, presumably associated with histamine release from degranulation of mast cells, and characterized …   Medical dictionary

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  • diffuse mastocytosis — diffuse cutaneous mastocytosis a condition in which the entire skin is thickened, lichenified, and leathery in appearance and accompanied by generalized erythroderma and intense pruritus as a result of widespread infiltration with mast cells. In… …   Medical dictionary

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