common variable immunodeficiency
- common variable immunodeficiency
- (CVID), common variable unclassifiable immunodeficiency a heterogeneous group of disorders characterized by hypogammaglobulinemia, decreased antibody production in response to antigenic challenge, and recurrent pyogenic infections, and often associated with hematologic and autoimmune disorders. Most patients have normal numbers of circulating B lymphocytes, which can identify antigens and proliferate, but lack plasma cells and appear to have an intrinsic defect of B cell differentiation. However, two other forms are also recognized: that due to a disorder of T lymphocyte regulation and that due to production of autoantibodies against T and B lymphocytes. Called also common variable agammaglobulinemia or hypogammaglobulinemia.
Medical dictionary.
2011.
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