hydroxymethylglutaryl-CoA reductase (NADPH)

hydroxymethylglutaryl-CoA reductase (NADPH)
hy·droxy·meth·yl·glu·ta·ryl-CoA re·duc·tase (NADPH) (hi-drok″se-meth″əl-glooґtə-rəl ko-aґ re-dukґtās) [EC 1.1.1.34] an enzyme of the oxidoreductase class that catalyzes the reduction of 3-hydroxy-3-methylglutaryl CoA to mevalonate, using NADPH as an electron donor. The reaction is a key rate-limiting step in the biosynthesis of cholesterol and the enzyme is inactivated by a specific kinase and reactivated by a specific phosphorylase.

Medical dictionary. 2011.

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