hydroxymethylglutaryl-CoA reductase (NADPH)
- hydroxymethylglutaryl-CoA reductase (NADPH)
- hy·droxy·meth·yl·glu·ta·ryl-CoA re·duc·tase (NADPH) (hi-drok″se-meth″əl-glooґtə-rəl ko-aґ re-dukґtās) [EC 1.1.1.34] an enzyme of the oxidoreductase class that catalyzes the reduction of 3-hydroxy-3-methylglutaryl CoA to mevalonate, using NADPH as an electron donor. The reaction is a key rate-limiting step in the biosynthesis of cholesterol and the enzyme is inactivated by a specific kinase and reactivated by a specific phosphorylase.
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Hydroxymethylglutaryl-CoA reductase (NADPH) — In enzymology, a hydroxymethylglutaryl CoA reductase (NADPH) (EC number|1.1.1.34) is an enzyme that catalyzes the chemical reaction:(R) mevalonate + CoA + 2 NADP+ ightleftharpoons (S) 3 hydroxy 3 methylglutaryl CoA + 2 NADPH + 2 H+The 3… … Wikipedia
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EC 3.1 — Le groupe EC3.1 est un groupe d hydrolases rassemblant les estérases, c est à dire les enzymes catalysant la réaction générale : R O R + H2O ⇌ R OH + R OH où R représente un acide quelconque et R son substrat. En fonction du milieu, l ester… … Wikipédia en Français
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