glycogen synthase

glycogen synthase
gly·co·gen syn·thase (gliґko-jən sinґthās) an enzyme of the transferase class that catalyzes the synthesis of glycogen by forming an α-1,4-glucoside linkage between the terminal hydroxyl group of glycogen chain and a glucosyl group donated by UDP-glucose. The reaction is highly regulated by allosteric effectors, by kinases and phosphatases, and by insulin. There are liver and muscle isoforms, each encoded by a separate gene; deficiency of either isoform, particularly the former, causes glycogen storage disease, type 0. In official nomenclature, called glycogen (starch) synthase.

Medical dictionary. 2011.

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  • Glycogen synthase — protein Name=glycogen synthase 1 (muscle) caption= width= HGNCid=4706 Symbol=GYS1 AltSymbols=GYS EntrezGene=2997 OMIM=138570 RefSeq=NM 002103 UniProt=P13807 PDB= ECnumber=2.4.1.11 Chromosome=19 Arm=q Band=13.3 LocusSupplementaryData=protein… …   Wikipedia

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