autoimmune gastritis

autoimmune gastritis
a rare type of chronic gastritis due to an autoimmune condition of the stomach, resulting from the presence of circulating autoantibodies against the parietal cells. Characteristics include inflammation and atrophy of the mucosa of the body of the stomach, with replacement of normal mucosa by antral, pseudopyloric, and intestinal metaplasia. Destruction of the mucosal glands results in achlorhydria and a decrease in production of intrinsic factor, in severe cases leading to failure of vitamin B12> absorption and pernicious anemia. Called also diffuse atrophic g., diffuse corporal atrophic g., and type A g.

Medical dictionary. 2011.

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