pyruvate dehydrogenase complex
- pyruvate dehydrogenase complex
- a multienzyme complex consisting of multimers of the three distinct enzymes: pyruvate dehydrogenase (acetyl-transferring) [EC 1.2.4.1], dihydrolipoyllysine-residue acetyltransferase [EC 2.3.1.12], and dihydrolipoyl dehydrogenase [EC 1.8.1.4]. The integrated enzyme complex requires the cofactors thiamine pyrophosphate, lipoic acid, coenzyme A, FAD, and NAD+. It catalyzes the formation of acetyl coenzyme A from pyruvate and coenzyme A, using NAD+ as an electron acceptor; the acetyl coenzyme A is used in fatty acid synthesis, for acetylations, and for oxidation via the tricarboxylic acid cycle. Deficiency of any component of the complex results in lacticacidemia, ataxia, and psychomotor retardation.
Medical dictionary.
2011.
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Pyruvate dehydrogenase complex — (PDC) is a complex of three enzymes that transform pyruvate into acetyl CoA by a process called pyruvate decarboxylation. Acetyl CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the… … Wikipedia
pyruvate dehydrogenase complex — py·ru·vate de·hy·dro·gen·ase com·plex (piґroo vāt de hiґdro jən ās komґpleks) see under complex … Medical dictionary
Pyruvate dehydrogenase (lipoamide) alpha 1 — PDB rendering based on 1ni4 … Wikipedia
Pyruvate dehydrogenase kinase — (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC number|2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP. PDK thus participates in the regulation of the… … Wikipedia
Pyruvate dehydrogenase deficiency — Classification and external resources ICD 10 E74.4 ICD 9 271.8 … Wikipedia
Pyruvate dehydrogenase — Crystallographic structure of pyruvate dehydrogenase (PDH). PH is a six domain dimer with α (blue), α’ (yellow), β (red), and β’ (teal) regions denoted by the different colors. Thiamine pyrophosphate (TPP) is shown in grey ball and stick form,… … Wikipedia
Pyruvate dehydrogenase (acetyl-transferring) — In enzymology, a pyruvate dehydrogenase (acetyl transferring) (EC number|1.2.4.1) is an enzyme that catalyzes the chemical reaction:pyruvate + [dihydrolipoyllysine residue acetyltransferase] lipoyllysine ightleftharpoons [dihydrolipoyllysine… … Wikipedia
pyruvate dehydrogenase (acetyl-transferring) — py·ru·vate de·hy·dro·gen·ase (ac·e·tyl trans·fer·ring) (piґroo vāt de hiґdro jən ās asґə təl transґfər ing) [EC 1.2.4.1] an enzyme of the oxidoreductase class that is a component of the multienzyme pyruvate… … Medical dictionary
[pyruvate dehydrogenase (acetyl-transferring)] kinase — [py·ru·vate de·hy·dro·gen·ase (ac·e·tyl trans·fer·ring)] ki·nase (piґroo vāt de hiґdro jən ās asґə təl transґfər ing kiґnās) [EC 2.7.11.2] an enzyme of the transferase class that catalyzes the phosphorylation of … Medical dictionary
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase — [py·ru·vate de·hy·dro·gen·ase (ac·e·tyl trans·fer·ring)] phos·pha·tase (piґroo vāt de hiґdro jən ās asґə təl transґfər ing fosґfə tās) [EC 3.1.3.43] an enzyme of the hydrolase class that catalyzes the… … Medical dictionary
