aminoglutethimide

aminoglutethimide
An aromatase inhibitor used in the treatment of breast cancer; blocks the synthesis of estrogen; formerly tried as an anticonvulsant but no longer used for that purpose.

* * *

ami·no·glu·teth·i·mide -glü-'teth-ə-.mīd n a glutethimide derivative C13H16N2O2 used esp. as an anticonvulsant

* * *

n.
an aromatase inhibitor used in the treatment of advanced breast and prostate cancer and Cushing's disease due to a malignant tumour. Because it inhibits synthesis of adrenal steroids (medical adrenalectomy), aminoglutethimide is usually given with corticosteroid replacement therapy. It is administered by mouth; side-effects, which are largely dose-related, may include drowsiness, dizziness, and a transient skin rash. Trade name: Orimeten.

* * *

ami·no·glu·teth·i·mide (ə-me″no-gloo-tethґĭ-mīd) [USP] an inhibitor of the enzymatic conversion of cholesterol to pregnenolone, thereby reducing corticosteroid synthesis and an aromatase inhibitor that inhibits conversion of androstenedione to estrone in peripheral tissues; used in the treatment of Cushing syndrome and as an investigational drug in the treatment of breast carcinoma; administered orally. It was formerly used as an anticonvulsant, but this use has been discontinued because of the adrenal suppressant effect.

Medical dictionary. 2011.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Aminoglutethimide — Systematic (IUPAC) name 3 (4 aminophenyl) 3 ethyl piperidine 2,6 dione Clinical data AHFS/Drugs.com …   Wikipedia

  • aminoglutethimide — An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors… …   English dictionary of cancer terms

  • aminoglutethimide — /euh mee noh glooh teth euh muyd , am euh noh /, n. Pharm. a hormone antagonist, C13H16N2O2, used in the treatment of Cushing s syndrome and breast cancer. [appar. from selected and rearranged syllables of aminophenyl and ethylglutarimide,… …   Universalium

  • aminoglutethimide — /euh mee noh glooh teth euh muyd , am euh noh /, n. Pharm. a hormone antagonist, C13H16N2O2, used in the treatment of Cushing s syndrome and breast cancer. [appar. from selected and rearranged syllables of aminophenyl and ethylglutarimide,… …   Useful english dictionary

  • Аминоглютетиамид (Aminoglutethimide) — лекарственный препарат, используемый в процессе лечения прогрессирующего рака груди. Препятствует синтезу стероидов надпочечниками (медицинская адреналэктомия), а также тормозит реакции периферического превращения андрогенов в эстрогсны.… …   Медицинские термины

  • АМИНОГЛЮТЕТИАМИД — (aminoglutethimide) лекарственный препарат, используемый в процессе лечения прогрессирующего рака груди. Препятствует синтезу стероидов надпочечниками (медицинская адреналэктомия), а также тормозит реакции периферического превращения андрогенов в …   Толковый словарь по медицине

  • Prostate cancer — is a disease in which cancer develops in the prostate, a gland in the male reproductive system. It occurs when cells of the prostate mutate and begin to multiply out of control. These cells may spread (metastasize) from the prostate to other… …   Wikipedia

  • Deflazacort — Systematic (IUPAC) name (11β,16β) 21 (acetyloxy) 11 hydroxy 2′ methyl 5′H pregna 1,4 dieno[17,16 d]oxazole 3,20 dione Clinical data AHFS/ …   Wikipedia

  • Cloprednol — Systematic (IUPAC) name (9S,10R,11S,13S,14S,17R) 6 chloro 11,17 dihydroxy 17 (2 hydroxyacetyl) 10,13 dimethyl 9,11,12,14,15,16 hexahydro 8H cyclopenta[a]phenanthren 3 one …   Wikipedia

  • Meprednisone — Systematic (IUPAC) name (16β) 17,21 dihydroxy 16 methylpregna 1,4 diene 3,11,20 trione Clinical data AHFS/Drugs.com …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”