aminoglutethimide

aminoglutethimide
An aromatase inhibitor used in the treatment of breast cancer; blocks the synthesis of estrogen; formerly tried as an anticonvulsant but no longer used for that purpose.

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ami·no·glu·teth·i·mide -glü-'teth-ə-.mīd n a glutethimide derivative C13H16N2O2 used esp. as an anticonvulsant

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n.
an aromatase inhibitor used in the treatment of advanced breast and prostate cancer and Cushing's disease due to a malignant tumour. Because it inhibits synthesis of adrenal steroids (medical adrenalectomy), aminoglutethimide is usually given with corticosteroid replacement therapy. It is administered by mouth; side-effects, which are largely dose-related, may include drowsiness, dizziness, and a transient skin rash. Trade name: Orimeten.

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ami·no·glu·teth·i·mide (ə-me″no-gloo-tethґĭ-mīd) [USP] an inhibitor of the enzymatic conversion of cholesterol to pregnenolone, thereby reducing corticosteroid synthesis and an aromatase inhibitor that inhibits conversion of androstenedione to estrone in peripheral tissues; used in the treatment of Cushing syndrome and as an investigational drug in the treatment of breast carcinoma; administered orally. It was formerly used as an anticonvulsant, but this use has been discontinued because of the adrenal suppressant effect.

Medical dictionary. 2011.

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