cytotropic antibody

cytotropic antibody
1. antibody that binds to mast cells and basophils at specific receptors; subsequent binding of antigen to the cell-fixed antibody triggers release of mediators of immediate hypersensitivity. Such antibodies produced by the animal itself in response to antigenic challenge or transferred from another animal of the same species (homocytotropic or reaginic antibodies or reagin) are always of the IgE class. In some cases IgG, IgA, or IgM from one species (heterocytotropic antibodies) can sensitize tissues of another species; e.g., rabbit IgG can sensitize guinea pig skin for passive cutaneous anaphylaxis.

Medical dictionary. 2011.

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