bradykinin

bradykinin
The nonapeptide Arg–Pro–Pro–Gly–Phe–Ser–Pro–Phe–Arg, produced from the decapeptide kallidin (bradykininogen) that is produced from α2-globulin by kallikrein, normally present in blood in an inactive form and similar to trypsin in action; b. is one of a number of the plasma kinins, is a potent vasodilator, and is one of the physiologic mediators of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody. SYN: kallidin 9, kallidin I, kinin 9. [brady- + G. kineo, to move]

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bra·dy·ki·nin -'kī-nən n a kinin that is formed locally in injured tissue, acts in vasodilation of small arterioles, is considered to play a part in inflammatory processes, and is composed of a chain of nine amino acid residues see KALLIDIN

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n.
a naturally occurring polypeptide consisting of nine amino acids. Bradykinin is a very powerful vasodilator and causes contraction of smooth muscle; it is formed in the blood under certain conditions and is thought to play an important role as a mediator of inflammation. See kinin.

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brady·ki·nin (brad″e-kiґnin) [brady- + Gr. kinein to move] a nonapeptide (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) produced by activation of the kinin system in a variety of inflammatory conditions. It is a potent vasodilator and also increases vascular permeability, stimulates pain receptors, and causes contraction of a variety of extravascular smooth muscles. The name refers to the slowly developing contraction produced in isolated guinea pig ileum. It is produced by the action of plasma kallikrein, trypsin, or plasmin on high-molecular-weight kininogen, a plasma α2-globulin, and is destroyed by several kininases in the lungs and other tissues.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Bradykinin — Masse/Länge …   Deutsch Wikipedia

  • bradykinin — ra dy*ki nin n. a hypotensive tissue hormone ({C50H73N15O11}) which acts on smooth muscle, dilates peripheral vessels and increases capillary permeability. It is formed locally in injured tissue and is believed to play a role in the inflammatory …   The Collaborative International Dictionary of English

  • bradykinin — [brad΄i kī′nin, brad΄ikin′in] n. [< BRADY + Gr kinein, to move: see KINETIC] a kinin, C50H73N15O11, released from blood plasma by some snake venoms and certain other enzymes, which slows intestinal contractions, lowers blood pressure, etc …   English World dictionary

  • Bradykinin — Chembox new ImageFile=Bradykinin.png ImageSize= IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=58 82 2 PubChem=6026 SMILES= MeSHName=Bradykinin Section2= Chembox Properties Formula=C50H73N15O11 MolarMass=1060.21 Appearance= Density=… …   Wikipedia

  • Bradykinin — Bra|dy|ki|nin [griech. bradýs = langsam; ↑ Kinin], das; s; Syn.: Kallidin I oder 9: durch ↑ Kallikrein aus Bradykininogen freigesetztes Peptid aus 9 Aminosäuren, das als ↑ Gewebshormon muskelkontrahierende, blutdrucksenkende u. schmerzauslösende… …   Universal-Lexikon

  • bradykinin — Vasoactive nonapeptide (RPPGFSPFR) formed by action of proteases on kininogens. Very similar to kallidin (which has the same sequence but with an additional N terminal lysine). Bradykinin is a very potent vasodilator and increases permeability of …   Dictionary of molecular biology

  • bradykinin — n. a naturally occurring polypeptide consisting of nine amino acids. Bradykinin is a very powerful vasodilator and causes contraction of smooth muscle; it is formed in the blood under certain conditions and is thought to play an important role as …   The new mediacal dictionary

  • Bradykinin receptor B2 — Bradykinin receptor B2, also known as BDKRB2, is a bradykinin receptor, but also denotes the human gene encoding it.MechanismThe B2 receptor is a G protein coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase …   Wikipedia

  • Bradykinin receptor B1 — Bradykinin receptor B1, also known as BDKRB1, is a human gene.Bradykinin, a 9 amino acid peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G protein coupled receptors have… …   Wikipedia

  • Bradykinin receptor — protein Name = bradykinin receptor B1 caption = width = HGNCid = 1029 Symbol = BDKRB1 AltSymbols = EntrezGene = 623 OMIM = 600337 RefSeq = NM 000710 UniProt = P46663 PDB = ECnumber = Chromosome = 14 Arm = q Band = 32.1 LocusSupplementaryData = 32 …   Wikipedia

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