α-N-acetylglucosaminidase

α-N-ac·e·tyl·glu·co·sa·min·i·dase (as″ə-təl-) (as″ə-tēl″gloo-kōs″ə-minґĭ-dās) [EC 3.2.1.50] a lysosomal hexosaminidase specifically catalyzing the cleavage of terminal, α-linked, nonreducing N-acetylglucosamine residues from glycosides; the reaction is necessary for the degradation of heparan sulfate. Deficiency of the enzyme, an autosomal recessive trait, results in Sanfilippo syndrome, type B.