topoisomerase inhibitor

topoisomerase inhibitor
any one of a class of cytotoxic drug that work by blocking the action of topoisomerase I, an enzyme that promotes the uncoiling of the DNA double helix, which is a necessary preliminary to replication. These drugs include irinotecan (Campto), used for treating advanced colorectal cancer; and topotecan (Hycamtin), for treating advanced ovarian cancer. They are administered by intravenous infusion; <

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any of a group of antineoplastic agents that interfere with the arrangement of DNA in cells.

Medical dictionary. 2011.

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  • topoisomerase inhibitor — any one of a class of cytotoxic drugs that work by blocking the action of topoisomerase I, an enzyme that promotes the uncoiling of the DNA double helix, which is a necessary preliminary to replication. These drugs include irinotecan (CPT11;… …   The new mediacal dictionary

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  • Type II topoisomerase — Type II topoisomerases cut both strands of the DNA helix simultaneously in order to change the linking number of the molecule. FunctionOnce cut, the ends of the DNA are separated, and a second DNA duplex is passed through the break. Following… …   Wikipedia

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