topoisomerase inhibitor

topoisomerase inhibitor
any one of a class of cytotoxic drug that work by blocking the action of topoisomerase I, an enzyme that promotes the uncoiling of the DNA double helix, which is a necessary preliminary to replication. These drugs include irinotecan (Campto), used for treating advanced colorectal cancer; and topotecan (Hycamtin), for treating advanced ovarian cancer. They are administered by intravenous infusion; <

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any of a group of antineoplastic agents that interfere with the arrangement of DNA in cells.

Medical dictionary. 2011.

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  • Topoisomerase inhibitor — Topoisomerase inhibitors are agents designed to interfere with the action of topoisomerase enzymescite web |url=http://www.cancer.gov/Templates/db alpha.aspx?CdrID=46665 |title=Definition of topoisomerase inhibitor NCI Dictionary of Cancer Terms… …   Wikipedia

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  • topoisomerase inhibitor — any one of a class of cytotoxic drugs that work by blocking the action of topoisomerase I, an enzyme that promotes the uncoiling of the DNA double helix, which is a necessary preliminary to replication. These drugs include irinotecan (CPT11;… …   The new mediacal dictionary

  • Topoisomerase — Topoisomerases (type I: EC 5.99.1.2, type II: EC 5.99.1.3) are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double helical structure. For example, during DNA… …   Wikipedia

  • topoisomerase II inhibitor RTA 744 — A substance being studied in the treatment of adult brain tumors. Topoisomerase II inhibitor RTA 744 crosses the blood brain barrier and blocks an enzyme needed for cancer growth. It is a type of topoisomerase inhibitor. Also called RTA 744 …   English dictionary of cancer terms

  • Type II topoisomerase — Type II topoisomerases cut both strands of the DNA helix simultaneously in order to change the linking number of the molecule. FunctionOnce cut, the ends of the DNA are separated, and a second DNA duplex is passed through the break. Following… …   Wikipedia

  • Dihydrofolate reductase inhibitor — A dihydrofolate reductase inhibitor is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic… …   Wikipedia

  • Nucleic acid inhibitor — Image illustrates DNA, RNA, and protein synthesis. The first two are nucleic acids. A Nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA… …   Wikipedia

  • Mitotic inhibitor — The structure of paclitaxel, a widely used mitotic inhibitor. A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules, which are structures that pull the cell apart when it divides. Mitotic… …   Wikipedia

  • Dihydropteroate synthase inhibitor — A dihydropteroate synthetase inhibitor is a drug that inhibits the action of dihydropteroate synthetase. Most are sulfonamides. Tetrahydrofolate synthesis pathway In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme …   Wikipedia

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