thymidine kinase

thymidine kinase
thymidine kinase n an enzyme that catalyzes the phosphorylation of thymidine in a pathway leading to DNA synthesis, that is active esp. in tissues undergoing growth or regeneration, and that is the key enzyme mediating replication in certain viruses (as the herpesvirus causing herpes simplex)

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thy·mi·dine ki·nase (TK) (thiґmĭ-dēn kiґnās) [EC 2.7.1.21] an enzyme of the transferase class that catalyzes the ATP-dependent phosphorylation of thymine deoxyribonucleoside, a reaction of pyrimidine salvage. Because the reaction produces an easily selectable phenotype, the gene and promoter are used extensively in genetic research.

Medical dictionary. 2011.

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  • Thymidine kinase 1 — Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase. [cite web | title = Entrez Gene: Thymidine kinase 1, soluble| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7083| accessdate = ]… …   Wikipedia

  • Thymidine kinase — protein Name = thymidine kinase 1, soluble caption = width = HGNCid = 11830 Symbol = TK1 AltSymbols = EntrezGene = 7083 OMIM = 188300 RefSeq = NM 003258 UniProt = P04183 PDB = ECnumber = 2.7.1.21 Chromosome = 17 Arm = q Band = 23.2… …   Wikipedia

  • Thymidine kinase et le virus de l'herpes simplex — Thymidine kinase et le virus de l herpès simplex Sommaire 1 Introduction 2 Caractéristique physiques et chimiques de tk hsv 3 VIROLOGIE 4 Pathologie …   Wikipédia en Français

  • Thymidine kinase et le virus de l'herpès simplex — Sommaire 1 Introduction 2 Caractéristique physiques et chimiques de tk hsv 3 VIROLOGIE 4 Pathologie …   Wikipédia en Français

  • thymidine kinase — Abbreviation: tk An enzyme that allows a cell to utilize an alternate metabolic pathway for incorporating thymidine into DNA. Used as a selectable marker to identify transfected eukaryotic cells …   Glossary of Biotechnology

  • thymidine kinase — noun : an enzyme that catalyzes the phosphorylation of thymidine in a pathway leading to DNA synthesis, that is active especially in tissues undergoing growth or regeneration, and that is the key enzyme mediating replication in certain viruses… …   Useful english dictionary

  • thymidine kinase — Enzyme of pyrimidine salvage, catalysing phosphorylation of thymine deoxyriboside to form its 5 phosphate, the nucleotide thymidylate. Animal cells lacking this enzyme can be selected by lethal synthesis, eg. by resistance to bromodeoxyuridine,… …   Dictionary of molecular biology

  • ADP-thymidine kinase — In enzymology, an ADP thymidine kinase (EC number|2.7.1.118) is an enzyme that catalyzes the chemical reaction:ADP + thymidine ightleftharpoons AMP + thymidine 5 phosphateThus, the two substrates of this enzyme are ADP and thymidine, whereas its… …   Wikipedia

  • AMP-thymidine kinase — In enzymology, an AMP thymidine kinase (EC number|2.7.1.114) is an enzyme that catalyzes the chemical reaction:AMP + thymidine ightleftharpoons adenosine + thymidine 5 phosphateThus, the two substrates of this enzyme are AMP and thymidine,… …   Wikipedia

  • Deoxycytidine kinase — PDB rendering based on 1p5z …   Wikipedia

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