Werner-His disease

Werner-His disease
Named for the German physician Heinrich Werner (who did not describe Werner's premature aging syndrome) and the Swiss physician Wilhelm His, Jr. (who did describe the bundle of His in the heart), this is a louse-borne disease that was first recognized in the trenches of World War I and so was called trench fever. Werner-His disease (trench fever) is estimated to have affected more than a million people in Russia and on the war fronts in Europe. Trench fever was again a major problem in the military in World War II and is seen endemically in Mexico, Africa, E. Europe, and elsewhere. Urban trench fever occurs among the homeless people and people with alcoholism today. Outbreaks have been documented, for example, in Seattle, Baltimore (among injection-drug users), Marseilles (France) and Burundi. The cause of trench fever is Bartonella quintana (also called Rochalimaea quintana), an unusual rickettsial organism that multiplies in the gut of the body louse. Transmission of the rickettsia to people can occur by rubbing infected louse feces into abraded (scuffed) skin or into the conjunctivae (whites of the eyes). The disease is classically a 5-day fever. The onset of symptoms is sudden with high fever, severe headache, back pain and leg pain and a fleeting rash. Recovery takes a month or more. Relapses are common. It is now clear, that at least in its urban form among the homeless, trench fever can be associated with nonspecific symptoms or no symptoms (New England Journal of Medicine 340: 184-189, 1999). The organism (B. quintana) that causes trench fever also has been found responsible for a disease called bacillary angiomatosis in people infected with HIV and for infection of the heart and great vessels (endocarditis) with bloodstream infection. Trench fever is also called Wolhynia fever, shin bone fever, quintan fever, five-day fever, Meuse fever, His disease, and His-Werner disease.

Medical dictionary. 2011.

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  • His disease — This is a parasite (louse borne) disease that was first recognized in the trenches of World War I and so was called trench fever. It is estimated to have affected more than a million people in Russia and on the war fronts in Europe. Trench fever… …   Medical dictionary

  • Disease, Werner-His — Named for the German physician Heinrich Werner (who did not describe Werner s premature aging syndrome) and the Swiss physician Wilhelm His, Jr. (who did describe the bundle of His in the heart), this is a louse borne disease that was first… …   Medical dictionary

  • His-Werner disease — This is a parasite (louse borne) disease that was first recognized in the trenches of World War I and so was called trench fever. It is estimated to have affected more than a million people in Russia and on the war fronts in Europe. Trench fever… …   Medical dictionary

  • Disease, His-Werner — Named for the Swiss physician Wilhelm His, Jr. (who also described the bundle of His in the heart) and the German physician Heinrich Werner (who was not the Werner who described Werner s syndrome). This is a louse borne disease that was first… …   Medical dictionary

  • Disease, His — Named for the Swiss physician Wilhelm His, Jr. (who also described the bundle of His in the heart), this is a louse borne disease first recognized in the trenches of World War I and so was called trench fever. Trench fever is a disease is… …   Medical dictionary

  • Werner syndrome — A premature aging disease that begins in adolescence or early in adulthood and results in apparent old age by 30 40 years of age. The characteristic features of Werner syndrome include short stature, premature graying and balding, wizened face,… …   Medical dictionary

  • Syndrome, Werner — A premature aging disease that begins in adolescence or early in adulthood and results in apparent old age by 30 40 years of age. The characteristic features of Werner syndrome include short stature, premature graying and balding, wizened face,… …   Medical dictionary

  • Heinrich Werner — (May 14, 1874 ndash; 1946) was a German physician who was born in Mühlhausen, Saxony. He studied medicine at the Kaiser Wilhelm Academy in Berlin, and later became a military medical officer in the German colonies of German East Africa, German… …   Wikipedia

  • Wilhelm His, Jr. — Wilhelm His, Jr. (born December 29, 1863, died November 10, 1934) was a Swiss born cardiologist and anatomist. In 1893, he discovered the bundle of His, which is a specialized tissue in the heart that transmits the electrical impulses and helps… …   Wikipedia

  • Werner syndrome — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 14096 ICD10 = ICD9 = ICD9|259.8 ICDO = OMIM = 277700 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshName = Werner+Syndrome MeshNumber = C16.320.925 Werner Syndrome (WRN) is a very rare,… …   Wikipedia

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