- An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks. Warfarin works by suppressing the production of some clotting factors (interfering with prothrombin activation) and thereby inhibiting the clotting of blood. Warfarin interacts with many other drugs, including some vitamins. These interactions can be dangerous, even life-threatening. If you are taking Warfarin, talk to your doctor before taking any other prescription or over-the-counter medications. University of Wisconsin biochemistry professor Karl Paul Link and his co-workers first isolated dicoumarin, a molecule in spoiled sweet clover that causes cattle to hemorrhage and die. The discovery led to the synthesis of Dicumarol, the first anticoagulant drug that could be taken orally. The successor to Dicumarol was Warfarin.
* * *war·fa·rin 'wȯr-fə-rən n a crystalline anticoagulant coumarin derivative C19H16O4 related to dicumarol that inhibits the production of prothrombin by vitamin K and is used as a rodent poison and in medicine also its sodium salt C19H15NaO4 used esp. in the prevention or treatment of thromboembolic disease see COUMADIN
* * *n.an anticoagulant used mainly in the treatment of coronary or venous thrombosis to reduce the risk of embolism. It is given by mouth. The principal toxic effect is local bleeding, usually from the gums and other mucous membranes. Warfarin has also been used as a rat poison. Trade name: Marevan.
* * *war·fa·rin (worґfər-in) [Wisconsin Alumni Research Foundation] a synthetic coumarin anticoagulant that acts by inhibiting the hepatic synthesis of vitamin Kâ€“dependent coagulation factors (prothrombin and factors VII, IX, and X) and proteins C and S. It also acts as a rodenticide, causing fatal hemorrhaging in any mammal that consumes a sufficient dose.
Medical dictionary. 2011.