An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks. Warfarin works by suppressing the production of some clotting factors (interfering with prothrombin activation) and thereby inhibiting the clotting of blood. Warfarin interacts with many other drugs, including some vitamins. These interactions can be dangerous, even life-threatening. If you are taking Warfarin, talk to your doctor before taking any other prescription or over-the-counter medications. University of Wisconsin biochemistry professor Karl Paul Link and his co-workers first isolated dicoumarin, a molecule in spoiled sweet clover that causes cattle to hemorrhage and die. The discovery led to the synthesis of Dicumarol, the first anticoagulant drug that could be taken orally. The successor to Dicumarol was Warfarin.

* * *

war·fa·rin 'wȯr-fə-rən n a crystalline anticoagulant coumarin derivative C19H16O4 related to dicumarol that inhibits the production of prothrombin by vitamin K and is used as a rodent poison and in medicine also its sodium salt C19H15NaO4 used esp. in the prevention or treatment of thromboembolic disease see COUMADIN

* * *

an anticoagulant used mainly in the treatment of coronary or venous thrombosis to reduce the risk of embolism. It is given by mouth. The principal toxic effect is local bleeding, usually from the gums and other mucous membranes. Warfarin has also been used as a rat poison. Trade name: Marevan.

* * *

war·fa·rin (worґfər-in) [Wisconsin Alumni Research Foundation] a synthetic coumarin anticoagulant that acts by inhibiting the hepatic synthesis of vitamin K–dependent coagulation factors (prothrombin and factors VII, IX, and X) and proteins C and S. It also acts as a rodenticide, causing fatal hemorrhaging in any mammal that consumes a sufficient dose.

Medical dictionary. 2011.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Warfarin — 1950, from WARF, acronym from Wisconsin Alumni Research Foundation + arin, from Coumarin. The organization describes itself as an independent, nonprofit foundation chartered to support research at the U[niversity of] W[isconsin] Madison and the… …   Etymology dictionary

  • warfarin — ► NOUN ▪ a water soluble compound with anticoagulant properties, used as a rat poison and in the treatment of thrombosis. ORIGIN from the initial letters of Wisconsin Alumni Research Foundation + arin …   English terms dictionary

  • warfarin — ☆ warfarin [wôr′fə rin ] n. [W(isconsin) A(lumni) R(esearch) F(oundation) + (COUM)ARIN] 1. a colorless, odorless, tasteless rat poison, C19H16O4, a crystalline powder that causes fatal internal bleeding in rodents 2. this drug neutralized with… …   English World dictionary

  • Warfarin — This article is about the drug with the brandname Coumadin. For the anticoagulant rodenticide poisons often called coumarins or coumadins , see 4 hydroxycoumarins. Warfarin …   Wikipedia

  • Warfarin — Strukturformel Allgemeines Freiname Warfarin Andere Namen …   Deutsch Wikipedia

  • Warfarin — 4 Hydroxy 3 (3 oxo 1 phenylbutyl) 2H 1 benzo pyran 2 on. Er en vitamin K antagonist, antikoagulant, anvendes til hindring af dannelse af blodpropper. Er endvidere anvendt som rottegift (rodenticid). Se også dicumarol. Warfarin er en hvid… …   Danske encyklopædi

  • warfarin — /wawr feuh rin/, n. Chem. 1. a colorless, crystalline, water insoluble anticoagulant, C19H16O4, used chiefly as a rodenticide. 2. Pharm. a preparation of this used in the management of potential or existing clotting disorders. [1945 50;… …   Universalium

  • warfarin — n. an anticoagulant used mainly in the prevention and treatment of deep vein thrombosis and pulmonary embolism and to prevent embolism in other patients at risk. It is given by mouth. The principal toxic effect is local bleeding, usually from the …   The new mediacal dictionary

  • Warfarin necrosis — Classification and external resources Examples of coumarin induced skin necrosis, late (left) and early (right) in the disease course. ICD 10 …   Wikipedia

  • Warfarin-Syndrom — Klassifikation nach ICD 10 Q86.2 angeborenen Fehlbildungssyndromen durch bekannte äußere Ursachen, die nicht andernorts klassifiziert werden …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”