platelet-activating factor

platelet-activating factor
plate·let-ac·ti·vat·ing factor -.ak-tə-.vāt-iŋ- n phospholipid that is produced esp. by mast cells and basophils, causes the aggregation of blood platelets and the release of blood-platelet substances (as histamine or serotonin), and is a mediator of inflammation (as in asthma) abbr. PAF

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(PAF) a substance released by basophils and mast cells in immediate hypersensitivity reactions and macrophages and neutrophils in other inflammatory responses; it is an extremely potent mediator of bronchoconstriction and of the platelet aggregation and release reactions. It differs from other known biochemical mediators in being a phospholipid. Called also PAF-acether or AGEPC (acetyl glyceryl ether phosphoryl choline).

Medical dictionary. 2011.

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